by Elsevier Primary chondrocytes overexpressing HDAC6 genetically were generated via plasmid transfection. The up-regulation of HDAC6 can deacetylate tubulin in the microtubule system, which interferes with spatial arrangement of mitochondria, leading to degradation of the extracellular matrix (ECM) and up-regulation of reactive oxygen species (ROS). Inhibition of enzyme activity of HDAC6 by Tubastatin A reverses these...
UNIVERSITY OF SOUTH AUSTRALIA Using new state-of-the-art imaging techniques to identify signs of osteoarthritis (OA), UniSA scientists are learning more about changes at the molecular level which indicate the severity of cartilage damage. A study led by PhD student Olivia Lee and her supervisor Associate Professor Paul Anderson using mass spectrometry imaging (MSI) has mapped...
by Joel Winston, Queen Mary, University of London A newly discovered molecule has been found to provide long-lasting regeneration of bone and cartilage defects, as well as symptom relief, and could potentially play a role in treating osteoarthritis, according to early research in animals led by Queen Mary University of London. Cartilage overlies bones to...
by NYU Langone Health The study results revolve around the long-established idea that machines within animal and human cells turn the sugars, fats, and proteins we eat into energy used by the body’s millions of cells. The molecule most used to store that energy is called adenosine triphosphate, or ATP. Along with this central role...
New study highlights the importance and potential promise of targeting structures other than cartilage pathology for the treatment of osteoarthritis BOSTON UNIVERSITY SCHOOL OF MEDICINE (Boston)– Bisphosphonates (a class of drugs that prevent the loss of bone density and used to treat osteoporosis and similar diseases) appear to be safe and beneficial for osteoarthritis patients....
UNIVERSITY OF CAMBRIDGE An algorithm that analyses MRI images and automatically detects small changes in knee joints over time could be used in the development of new treatments for arthritis. A team of engineers, radiologists and physicians, led by the University of Cambridge, developed the algorithm, which builds a three-dimensional model of an individual’s knee...
by Boston University School of Medicine Wearing shoes specifically designed with a novel sole (biomechanical footwear) significantly reduces the pain associated with knee osteoarthritis. Knee osteoarthritis affects approximately 275 million people worldwide and in 2017 was estimated to account for 8.3 million years lived with disability. Acetaminophen, non-steroidal anti-inflammatory drugs and opioids are most commonly...
Researchers have found that adult skates have the ability to spontaneously repair injured cartilage, using a type of cartilage stem cell. Human cartilage has very limited capacity for repair, and the finding may lead to new stem cell treatments for human cartilage injuries. Published in the journal eLife, the study identified a new type of...
Osteoarthritis is a disease, characterized by the breakdown of joint cartilage and underlying bone. It typically affects hands, but can also damage feet, spine, and the large weight-bearing joints. Small joints in hands are difficult to repair, but now scientists at the University of Twente have developed a radically new implant, which does not even...
by American College of Rheumatology Research presented at the 2019 ACR/ARP Annual Meeting found that a six-week treatment with low-dose oral prednisolone substantially improves pain and decreases signs of inflammation in patients with painful hand osteoarthritis (Abstract #1760). Osteoarthritis (also known as OA) is a common joint disease that most often affects middle-age to elderly...
