by Molly Chiu, Baylor College of Medicine Figure 1. Transcriptomic and bioinformatics analyses demonstrate activation of TGF-β signaling in OI type III bone. (A) Principal component analysis (PCA) plot of transcriptomic data from non-OI and OI type III bones in 3-PC dimensions. (B) Hierarchical clustering based on Euclidian distance using RPKM of all non-OI and...
MEDICAL UNIVERSITY OF SOUTH CAROLINA IMAGE: MEENAL MEHROTRA, ASSISTANT PROFESSOR IN THE DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE AT MUSC HEALTH AND PRINCIPAL INVESTIGATOR ON THE PAPER, POINTS TO A MUTATION IN THE COLLAGEN GENE AS THE MAJOR CAUSE OF THE WEAK BONES THAT COME WITH OSTEOGENESIS IMPERFECTA CREDIT: ANNE THOMPSON, MUSC HEALTH Most people...
by Baylor College of Medicine Credit: Pixabay/CC0 Public Domain Osteogenesis imperfecta (OI) is the most common genetic form of brittle bone disease and results in defects of both bone and connective tissue. OI patients can have significant problems with mobility due to joint dysfunction due in part to tendinopathy. In a new study published in the...
