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Protein blocking bone development could hold clues for future osteoporosis treatment

Credit: CC0 Public Domain Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation. In their paper published in Communications Biology 11 October 2024, a team of researchers led by Dr. Amy Naylor and Professor Roy Bicknell along with their team...

Osteoporosis treatments may benefit from discovery of key driver of low bone density
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Osteoporosis treatments may benefit from discovery of key driver of low bone density

VAN ANDEL RESEARCH INSTITUTE IMAGE: DR. CONNIE KRAWCZYK CREDIT: COURTESY OF VAN ANDEL INSTITUTE. GRAND RAPIDS, Mich. (April 19, 2023) — Van Andel Institute scientists have pinpointed a key driver of low bone density, a discovery that may lead to improved treatments with fewer side effects for women with osteoporosis. The findings are described in a study published this month in Science...

Naturally occurring hormone could offer a better osteoporosis treatment
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Naturally occurring hormone could offer a better osteoporosis treatment

By Ben Coxworth April 14, 2022 The hormone kisspeptin has been shown to help restore the balance between bone-building and bone-degrading cells Depsoitphotos Osteoporosis is characterized by the deterioration of bone tissue, resulting in weak bones that are easily broken. There may be new hope for treating the disease, however, utilizing a naturally occurring hormone....

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Study identifies potential target for osteoporosis treatments

ELIFE Channels on the surface of bone cells called osteocytes help build stronger bones in response to mechanical stress, shows a study published today in eLife. This discovery may help scientists develop new treatments for osteoporosis or other conditions that contribute to bone loss in patients. Physical activities that exert mechanical stress on the bones...

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New type of bone cell could reveal targets for osteoporosis treatment

GARVAN INSTITUTE OF MEDICAL RESEARCH Researchers at the Garvan Institute of Medical Research have discovered a new type of bone cell that may reveal new therapeutic approaches for osteoporosis and other skeletal diseases. The new cells, which the researchers term ‘osteomorphs’, are found in the blood and bone marrow, and fuse together to form osteoclasts, specialised cells that...