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Bacteria can ‘outsmart’ programmed cell death

UNIVERSITY OF COLOGNE Certain bacteria can override a defence mechanism of the immune system, so called programmed cell death, through inhibition of death effector molecules by their outer membranes components. Shigella bacteria, which cause diarrhoea, use lipopolysaccharides (LPS) on their surface to block the effector caspases. Lipopolysaccharides are a component of the bacterial outer membrane....