by Will Doss, Northwestern University Figure 1. Tissue transglutaminase (TG2) promotes peritoneal tumor growth in a syngeneic ovarian cancer (OC) mouse model by preventing CD8+ T cell infiltration into ascites. (A, B) Volume of peritoneal ascites (mean±SEM, n=23 per group, cumulative data from four independent experiments are shown) (A), and numbers of cells in ascites (mean±SEM,...
by Institute of Cancer Research Credit: Jan Chlebik, ICR Immune-related genes are associated with the development of the rare cancer ovarian clear cell carcinoma (OCCC), new research has found. A new study led by researchers at the Institute of Cancer Research, London, investigated the immune characteristics of OCCC and uncovered gene alterations linked to poor prognosis for the disease. It also identified specific immune cells that...
by Jenni Ho, University of Kentucky Fig 1. Ovarian cancer cell lines exhibit varied responses to paclitaxel treatment. Paclitaxel-resistant (PacR) and parental control ovarian cancer cell lines, TOV-21G and OVCAR3, were treated with serially diluted doses of paclitaxel for 96 hours in vitro. Cell viability is displayed at each concentration tested relative to untreated cells for...
THE WISTAR INSTITUTE IMAGE: WISTAR’S DR. RUGANG ZHANG CREDIT: THE WISTAR INSTITUTE PHILADELPHIA — (Sept. 21, 2021) —Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress...
by Jeff Hansen, University of Alabama at Birmingham Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumour. H&E stain. The micrograph shows Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left – diagnostic of an LMP tumour). Epithelium in a frond-like architecture is seen at the top of the image. Credit: Nephron...
A study led by researchers at the University of Minnesota Medical School found a way to detect the presence of ovarian cancer in patients using Pap test samples, normally used to detect cervical cancer. Currently, no early warning system exists for ovarian cancer, which in 2021, is estimated to kill more than 13,700 women, according to the American...
By STEPHEN ADAMS MEDICAL EDITOR FOR THE MAIL ON SUNDAY PUBLISHED: 17:03 EST, 13 February 2021 | UPDATED: 17:16 EST, 13 February 2021 Women who have ovarian cancer are to receive a new vaccine that experts hope could give them years of extra life. Survival rates for the disease, which claims more than 4,000 lives a year in Britain, are low...
IMPACT JOURNALS LLC IMAGE: Schematic diagram of the molecular action of 2MeOE2. 2MeOE2 -mediated pro-apoptotic actions involve the catalytic activation of PKCδ by cellular caspases. The catalytic fragment of PKCδ is responsible for the apoptotic histone modifications in the nucleus and activates p38 MAPK pathway in the cytosol, which induces more activation of caspases that...
by The Wistar Institute Ovarian cancer cells. Credit: The Wistar Institute Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute published online in Nature Cancer. Researchers also showed that pharmacologic inhibition of glutamine metabolism may represent an...
by University of Exeter Credit: CC0 Public Domain A blood test already available to GPs in the UK is more predictive of ovarian cancer than previously thought and could also help pick up other forms of cancer, according to new research published in PLOS Medicine today (Wednesday) and funded by Cancer Research UK and NIHR. This study involving...
