Tag: <span>P53 Cancer control switch</span>

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Compound discovered that targets cancer cells lacking the protective p53 ‘guardian gene’

Developed and tested at the University of Huddersfield, the compound, containing ruthenium, is attracted to the vulnerable cancer cells, whilst leaving healthy cells untouched UNIVERSITY OF HUDDERSFIELD A NEW chemical compound with the potential to destroy hard-to-treat cancer cells has been developed and tested by scientists at the University of Huddersfield.  Also, the compound causes...

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P53 ‘master switch’ remains top target in gene signaling network controlling cancer

The lab of Joaquin Espinosa, Ph.D., find no essential “second in command” in gene signaling network controlled by tumor-suppressor gene p53.   There are two important categories of genes involved in cancer development, oncogenes and tumor suppressor genes. When oncogenes gain function, e.g. through mutation, they actively promote cancer – drugs that turn them off...