by Tokyo Metropolitan University Two different ways in which islet cell loss can be observed (top left and right) . The relationship between the percentage of pancreatic beta cells and islet cell loss (bottom left). The number of mild and severe cases of ICL at different ages (bottom right). Credit: Tokyo Metropolitan UniversityResearchers from Tokyo Metropolitan...
by Bill Snyder, Vanderbilt University Method for quantification of ADM lobules. ADM-positive lobules (outlined in green) were tallied per section. Total pancreatic tissue (orange) was outlined manually and quantified. ADM score was determined by dividing the total number of ADM-positive lobules (across head, body, and tail regions) by the total tissue area. Scale bar = 2mm....
by Joel Streed, Mayo Clinic Credit: Pixabay/CC0 Public Domain Simply put, pancreatitis is inflammation of the pancreas. Located behind the stomach in the upper abdomen, your pancreas produces digestive enzymes and hormones that regulate how your body produces sugar. Pancreatitis is caused by the irritation and inflammation of the cells of your pancreas. This occurs when digestive enzymes released...
by Salk Institute Left: Healthy pancreas. Right: Extensive pancreatic scarring (purple) when ERR gamma is lost from acinar cells. Credit: Salk Institute Every day, your pancreas produces about one cup of digestive juices, a mixture of molecules that can break down the food you eat. But if these powerful molecules become activated before they make...
by Tyrel Linkhorn, University of Toledo Dr. Juan Jaume’s promising research could revolutionize management of a disease affecting an estimated 1.6 million Americans. Credit: University of Toledo Promising research from The University of Toledo suggests it might be possible to cure Type I diabetes by reprogramming a patient’s own immune cells to heal the pancreas...
VANDERBILT UNIVERSITY IMAGE: PANCREATIC ACINAR CELLS FORM A HETEROGENEOUS POPULATION OF NEW CELL TYPES IN RESPONSE TO INJURY WITH THE POTENTIAL TO LIMIT OR DRIVE DISEASE. ACINAR-DERIVED CLONES LABELED IN RED AND GREEN. CREDIT: DELGIORNO, ET. AL. The Idea Pioneering research from scientists at the Vanderbilt University School of Medicine Basic Sciences and the Salk...
by La Jolla Institute for Immunology Yellow staining shows CD*+T cells poised to target preproinsulin. The white outline on the right shows the perimeter of an insulin-containing islet in a patient with type 1 diabetes. The image shows that the preproinsulin-specific T cells can wait very close islets, probably poised to destroy the beta cells inside....
by Huntsman Cancer Institute Scientists at Huntsman Cancer Institute at the University of Utah report today the development of new models to study molecular characteristics of tumors of the lung and pancreas that are driven by mutations in a gene named NTRK1. The findings were published today in the journal Cell Reports. Credit: Huntsman Cancer...
by Salk Institute Persistent inflammation of the pancreas (chronic pancreatitis) is a known risk factor for developing pancreatic cancer, the third-deadliest cancer in the United States. Tuft cells—cells sensitive to chemical (chemosensory) changes typically found in the intestines and respiratory tract—had previously been discovered in the pancreas, but their function has largely remained a mystery....
Researchers reveal how pancreatic ß-cells respond to an inflammatory environment and its implication in developing Type 1 diabetes JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE Researchers Lorenzo Pasquali and Mireia Ramos-Rodríguez have published recently in Nature Genetics the results of a study on the mechanisms that cause an inflammatory response to trigger pancreatic beta-cell death, leading to...
