The green line represents male mice with pancreatic cancer-causing genes and expressing half the normal amount of GRP78 protein. These mice survived longer than those that had pancreatic cancer-causing genes, but normal levels of GRP78, …more New research from the Keck School of Medicine of the University of Southern California (USC) shows new promise in...
Tag: <span>Pancreatic cancer</span>
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UCLA scientists combine a peptide with a nano cancer drug formulation to improve treatment effectiveness and prevent metastasis in pancreatic cancer
Study shows the peptide enhances a vascular access pathway for nanocarriers in pancreatic cancer UCLA scientists have unlocked an important mechanism that allows chemotherapy-carrying nanoparticles – extremely small objects between 1 and 100 nanometers (a billionth of a meter) – to directly access pancreatic cancer tumors, thereby improving the ability to kill cancer cells and hence leading to more...
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High rate of tumor shrinkage among pancreatic cancer patients: study
Adding cisplatin to the standard gemcitabine/nab-paclitaxel drug treatment provided a very high rate of tumor shrinkage for patients with advanced pancreatic cancer, according to the results of a pilot clinical trial conducted by the HonorHealth Research Institute and the Translational Genomics Research Institute (TGen). These statistically significant and clinically meaningful improvements in overall response and...
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Researchers find novel way to induce pancreatic cancer cell death
Pancreatic cancer: Pancreatic cancer, most frequently pancreatic ductal adenocarcinoma (PDAC), is the most lethal and aggressive of all cancers. Unfortunately, there are not many effective therapies available other than surgery, and that is not an option for many patients. scientists at Wake Forest Baptist Medical Center in collaboration with those at the University of Texas...
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Researchers find novel way to induce pancreatic cancer cell death
Axial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Pancreatic cancer, most frequently pancreatic ductal adenocarcinoma (PDAC), is the most lethal and aggressive of all cancers. Unfortunately, there are not many effective therapies available other than surgery, and that is not an option for many patients. In an effort to better...
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Protein identified as potential druggable target for pancreatic cancer
A protein known as arginine methyltransferase 1 (PRMT1) may be a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, and one of the most deadliest with a less than 10 percent, five-year survival rate. PRMT1 is involved in a number of genetic processes including gene transcription, DNA repair...
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Light scattering spectroscopy helps doctors identify early pancreatic cancer
Pancreatic cancer has the lowest survival rate among all major cancers, largely because physicians lack diagnostic tools to detect the disease in its early, treatable stages. Now, a team of investigators led by Lev T. Perelman, PhD, Director of the Center for Advanced Biomedical Imaging and Photonics at Beth Israel Deaconess Medical Center (BIDMC), has...
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Why is pancreatic cancer so hard to treat? Stroma provides new clues
In the dense stromal tissue that envelops pancreatic tumors, Tuveson and colleagues have discovered two varieties of a cell type called fibroblasts which help create the stroma. One of these varieties is seen in left image: fibroblasts (red) close to proliferating cancer cells (green) that express high levels of a protein called aSMA. In the...
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Tumor protein could hold key to pancreatic cancer survival
But research led by the University of Melbourne reported in the International Journal of Cancer, could eventually improve treatments with the identification of a protein that appears to help tumour cells become more aggressive. In Australia this year, some 3,200 new cases of Pancreatic cancer will be diagnosed, and 2,900 patients will die of the disease....
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Diabetes or its rapid deterioration can be an early warning sign for pancreatic cancer
Patients and their doctors should be aware that the onset of diabetes, or a rapid deterioration in existing diabetes that requires more aggressive treatment, could be a sign of early, hidden pancreatic cancer, according to research presented at the European Cancer Congress 2017 today (Monday). Ms Alice Koechlin, from the International Prevention Research Institute in...