Patricia McKnight November 04, 2022 Women with polycystic ovary syndrome (PCOS) may be at a higher risk of developing pancreatic cancer, say researchers reporting a single-center case-control study. A diagnosis of PCOS was associated with a 1.9-fold higher risk of pancreatic cancer after adjusting for age, race, ethnicity, estrogen level, and diabetes. This is the second study to find such...
Tag: <span>Pancreatic cancer</span>
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Gel-like, radioactive tumor implant obliterates pancreatic cancer in mice
by Ken Kingery, Duke University Credit: Unsplash/CC0 Public Domain Biomedical engineers at Duke University have demonstrated the most effective treatment for pancreatic cancer ever recorded in mouse models. While most mouse trials consider simply halting growth a success, the new treatment completely eliminated tumors in 80% of mice across several model types, including those considered...
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Two drugs reverse a key pancreatic cancer step in the lab
by University of Florida Reversal of ADM by TSA in primary human acinar cultures. Primary, human acini were cultured in Matrigel on glass chamber slides for 5 days. On day 5 of culture, 500 nM of TSA was added and the cells were cultured for 5 additional days. The cells were processed for immunohistochemistry and imaged...
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Researchers find tumor microbiome interactions may identify new approaches for pancreatic cancer treatment
by Rutgers University Credit: Pixabay/CC0 Public Domain Investigators from Rutgers Cancer Institute of New Jersey, the state’s leading cancer center and only National Cancer Institute-Designated Comprehensive Cancer Center, together with RWJBarnabas Health, examined the microbiome of pancreatic tumors and identified particular microorganisms at single cell resolution that are associated with inflammation and with poor survival....
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Pitt-developed genetic test for pancreatic cancer outperforms current guidelines
UNIVERSITY OF PITTSBURGH PITTSBURGH, Oct. 5, 2022 — A molecular test called PancreaSeq accurately classifies pancreatic cysts as potentially cancerous or benign, according to a large, multi-center study led by University of Pittsburgh School of Medicine and UPMC researchers. Published today in Gastroenterology, the prospective study of more than 1,800 patients found that incorporating molecular markers improved the accuracy of diagnoses compared...
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Researchers identify potential gene marker for treating pancreatic cancer
by Joe Dangor, Mayo Clinic Credit: Mayo Clinic Researchers at Mayo Clinic Comprehensive Cancer Center have identified a gene marker that may lead to a more effective, precision treatment for pancreatic ductal adenocarcinoma (PDAC). The researcher’s findings are published in Nature Cancer. “Pancreatic ductal adenocarcinoma is one of the most lethal cancers,” says the paper’s senior...
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Research team reveals mechanisms at work in progression of pancreatic cysts to pancreatic cancer
by University of California, San Francisco Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer Institute Pancreatic cysts have gained substantial attention in recent years because they represent one of the only precursors of pancreatic cancer identifiable through radiologic imaging. Although most of these cysts, also known as pancreatic...
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Pancreatic cancer clinical trial to test new approach to treatment
A clinical trial into pancreatic cancer treatment will explore findings from the Garvan Institute of Medical Research that suggest a new targeted treatment can make the tumours more susceptible to chemotherapy and improve patient survival rates. A blood test. Image credit: U.S. Air Force photo by Staff Sgt. Teresa J. Cleveland, Public Domain via Health.mil The new trial...
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AI applied to prediagnostic CTs may help diagnose pancreatic cancer at earlier, more treatable stage
MAYO CLINIC ROCHESTER, Minn. — A study published in Gastroenterology finds that radiomics-based machine learning models may detect pancreatic cancer on prediagnostic CT scans substantially earlier than current methods for clinical diagnosis. “Pancreatic cancer is a deadly disease and a leading cause of cancer-related death,” says Ajit Goenka, M.D., a Mayo Clinic diagnostic radiologist and the...
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Preclinical study: Three-step treatment strategy for pancreatic cancer
by Cedars-Sinai Medical Center Axial CT image with i.v. contrast. Macrocystic adenocarcinoma of the pancreatic head. Credit: public domain Research led by investigators at Cedars-Sinai Cancer and Johns Hopkins University have discovered a novel three-step treatment that disrupts the pancreatic tumor microenvironment in laboratory mice. The preclinical study, published in the journal Gastroenterology, focuses on a trio...