News Release 31-Jul-2024 Peer-Reviewed PublicationUniversity of Cologne Researchers from the University of Cologne have revealed a mechanism protecting pancreatic β-cells, which are crucial for insulin production from inflammatory cell death. The study investigated the role of receptor-interacting protein kinase 1 (RIPK1) in regulating β-cell survival. Typically, this protein controls cell fate by balancing survival and...
Tag: <span>pancreatic cells</span>
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Boosting function and survival of stem cell-derived pancreatic cells by genetic engineering
by International Society for Stem Cell Research Credit: CC0 Public Domain Recent advances in the transplantation of stem cell-derived insulin-producing beta cells (SC-beta cells) to treat type 1 diabetes (T1D) has generated considerable interest and excitement. A major obstacle to the long-term survival and functioning of SC-beta cells is their vulnerability to stress or attacks...
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Small protein protects pancreatic cells in model of type 1 diabetes
by Beth Newcomb, University of Southern California n mice that had been genetically engineered to develop autoimmune diabetes, “killer” T-cells (darker spots) infiltrate and destroy insulin-producing cells in the pancreas (left). Treatment with injections of MOTS-c reduced T-cell infiltration and prevented the onset of the disease (right). Credit: University of Southern California A new study has...
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Researchers develop new way to watch pancreatic cells package insulin
by University of Southern California Scientists develop new methods to peer deeply inside insulin-producing pancreas cells. Credit: Katya Kadyshevskaya For the first time, scientists have peered deeply inside a pancreatic cell and observed it packaging insulin and responding to a drug treatment, an intimate look at the mechanisms responsible for preventing diabetes. A team of scientists—led...