Tag: <span>Pancreatic Endoderm Cells</span>

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Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site

Highlights hESC-derived PECs in a prevascularized device-less site routinely reverse diabetes Device-less PEC grafts functioned better than fat pad and subcutaneous PEC grafts Human C-peptide secretion was glucose regulated in device-less PEC grafts Safely retrieved grafts stained positive for insulin, glucagon, and somatostatin Summary Beta-cell replacement therapy is an effective means to restore glucose homeostasis...