by Kumamoto University The trigger for neurodegeneration is the assembly of G4 structures driven by increased intracellular calcium ions (Ca2+) due to cellular stress. α-Synuclein binds directly to G4, shifting into an aggregate-prone structure that employs G4 as a scaffold to form harmful clusters. Therefore, inhibiting G4 assembly can prevent α-synuclein aggregation, helping to protect against...
Tag: <span>Parkinson’s disease</span>
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Parkinson’s disease a promising treatment- pharmaceutical
Parkinson’s disease: finally a promising treatment© Unsplash A sparkling shot… almost magical, to treat Parkinson’s. American researchers have conducted several clinical trials, rather encouraging. Gold nanocrystals that could restore molecules affected by neurodegenerative diseases? Really? To understand how they work, let’s take a quick look at “biology”. The brain, in order to function properly, needs a...
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Hearing loss linked to increased Parkinson’s risk in veterans
by Justin Jackson , Medical Xpress Credit: Pixabay/CC0 Public Domain Oregon Health & Science University-led researchers have found a correlative link between hearing loss and the development of Parkinson’s disease (PD). They find the risk of PD rises somewhat with the severity of hearing loss, and declines when hearing aids are promptly issued. Previous studies...
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FDA approves Vyalev for advanced Parkinson’s disease
by Lori Solomon The U.S. Food and Drug Administration has approved AbbVie’s Vyalev (foscarbidopa and foslevodopa) for adults living with advanced Parkinson’s disease (PD). Vyalev is the first and only subcutaneous 24-hour continuous infusion of levodopa-based therapy for the treatment of motor fluctuations in advanced PD and allows for personalized dosing throughout the day based...
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Parkinson’s disease may one day be treated with a shot of magnetic discs
This diagram illustrates how the hexagonal MENDs discs (top) are able to electrically stimulate a neuron (pink) MIT View 2 Images Although brain-implanted electrodes do help minimize the effects of Parkinson’s disease and other neurological disorders, implanting and activating those electrodes can be a tricky process. That’s why scientists are now developing an alternative, in the form...
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Direct Brain A-Dopamine Infusion Promising for Parkinson’s Disease
Patrice Wendling October 02, 2024 PHILADELPHIA — Continuous intracerebroventricular administration of an anaerobic dopamine formulation (A-dopamine) appears safe in patients with Parkinson’s disease (PD) and may avoid complications associated with levodopa, results from a first in-human trial suggest. A-dopamine induced a dose-dependent improvement in motor symptoms in refractory patients with severe levodopa complications and had...
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For people with Parkinson’s, moving is a mental challenge as well as a physical one
Distribution of participant scores on different tasks. (A) Index scores generated from mental chronometry of the box and blocks task are shown for the more affected versus less affected side. (B) Density plots represent distribution of index scores and our predictors of interest. Credit: Brain and Cognition (2024). DOI: 10.1016/j.bandc.2024.106181 It’s well known that Parkinson’s disease can...
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Direct Brain A-Dopamine Infusion Promising for Parkinson’s Disease
PHILADELPHIA — Continuous intracerebroventricular administration of an anaerobic dopamine formulation (A-dopamine) appears safe in patients with Parkinson’s disease (PD) and may avoid complications associated with levodopa, results from a first in-human trial suggest. A-dopamine induced a dose-dependent improvement in motor symptoms in refractory patients with severe levodopa complications and had a “really great” safety profile, said study investigator...
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Genetics suggest link between ALS and Parkinson’s disease
September 16, 2024 by Dennis Thompson People with rare genetic variants linked to degenerative brain disorders like Parkinson’s disease are at increased risk of developing ALS, a new study finds. Further, having these genetic variants increases the risk of a person having faster-progressing ALS (amyotrophic lateral sclerosis) and dying earlier, researchers found. The strongest link...
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Studying the brain in motion offers new insights into Parkinson’s disease
September 5, 2024 by Andrew Dunne, Horizon: The EU Research & Innovation Magazine Credit: CC0 Public DomainA breakthrough in medical imaging is making it possible for researchers to observe brain activity during movement and pick up the early signs of disorders that affect brain-to-body coordination, such as Parkinson’s disease. The researchers are advancing new technology...