Peer-Reviewed Publication Intelligent Computing image: The pipeline illustrates how EEG signals are processed for Parkinson’s disease detection. Key features are extracted from brainwave data and transformed into images or movie representations. These are then analyzed using machine learning models to classify emotional responses, high and low valence and arousal, and differentiate patients with Parkinson’s disease...
Tag: <span>Parkinson’s disease</span>
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Receptor structure reveals novel drug design opportunities for Parkinson’s disease
by Justin Jackson , Medical Xpress Top and side views of GPR6 structures in different conformational states. Credit: Science Signaling (2024). DOI: 10.1126/scisignal.ado8741 University of Southern California-led researchers have discovered the structural details of a brain receptor called GPR6, which could lead to new treatments for Parkinson’s disease. GPR6 is an orphan G protein-coupled receptor primarily expressed...
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RNA structures present a promising target for early intervention in Parkinson’s disease
by Kumamoto University The trigger for neurodegeneration is the assembly of G4 structures driven by increased intracellular calcium ions (Ca2+) due to cellular stress. α-Synuclein binds directly to G4, shifting into an aggregate-prone structure that employs G4 as a scaffold to form harmful clusters. Therefore, inhibiting G4 assembly can prevent α-synuclein aggregation, helping to protect against...
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Parkinson’s disease a promising treatment- pharmaceutical
Parkinson’s disease: finally a promising treatment© Unsplash A sparkling shot… almost magical, to treat Parkinson’s. American researchers have conducted several clinical trials, rather encouraging. Gold nanocrystals that could restore molecules affected by neurodegenerative diseases? Really? To understand how they work, let’s take a quick look at “biology”. The brain, in order to function properly, needs a...
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Hearing loss linked to increased Parkinson’s risk in veterans
by Justin Jackson , Medical Xpress Credit: Pixabay/CC0 Public Domain Oregon Health & Science University-led researchers have found a correlative link between hearing loss and the development of Parkinson’s disease (PD). They find the risk of PD rises somewhat with the severity of hearing loss, and declines when hearing aids are promptly issued. Previous studies...
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FDA approves Vyalev for advanced Parkinson’s disease
by Lori Solomon The U.S. Food and Drug Administration has approved AbbVie’s Vyalev (foscarbidopa and foslevodopa) for adults living with advanced Parkinson’s disease (PD). Vyalev is the first and only subcutaneous 24-hour continuous infusion of levodopa-based therapy for the treatment of motor fluctuations in advanced PD and allows for personalized dosing throughout the day based...
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Parkinson’s disease may one day be treated with a shot of magnetic discs
This diagram illustrates how the hexagonal MENDs discs (top) are able to electrically stimulate a neuron (pink) MIT View 2 Images Although brain-implanted electrodes do help minimize the effects of Parkinson’s disease and other neurological disorders, implanting and activating those electrodes can be a tricky process. That’s why scientists are now developing an alternative, in the form...
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Direct Brain A-Dopamine Infusion Promising for Parkinson’s Disease
Patrice Wendling October 02, 2024 PHILADELPHIA — Continuous intracerebroventricular administration of an anaerobic dopamine formulation (A-dopamine) appears safe in patients with Parkinson’s disease (PD) and may avoid complications associated with levodopa, results from a first in-human trial suggest. A-dopamine induced a dose-dependent improvement in motor symptoms in refractory patients with severe levodopa complications and had...
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For people with Parkinson’s, moving is a mental challenge as well as a physical one
Distribution of participant scores on different tasks. (A) Index scores generated from mental chronometry of the box and blocks task are shown for the more affected versus less affected side. (B) Density plots represent distribution of index scores and our predictors of interest. Credit: Brain and Cognition (2024). DOI: 10.1016/j.bandc.2024.106181 It’s well known that Parkinson’s disease can...
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Direct Brain A-Dopamine Infusion Promising for Parkinson’s Disease
PHILADELPHIA — Continuous intracerebroventricular administration of an anaerobic dopamine formulation (A-dopamine) appears safe in patients with Parkinson’s disease (PD) and may avoid complications associated with levodopa, results from a first in-human trial suggest. A-dopamine induced a dose-dependent improvement in motor symptoms in refractory patients with severe levodopa complications and had a “really great” safety profile, said study investigator...