by Stony Brook University Whole-cell recordings of excitatory neurons in forelimb M1 were localized to L2/3 and L5. A, Schematic showing the anterior–posterior span of recorded slices, restricted to the forelimb area of M1. B, Recorded neurons were visualized with streptavidin labeling of biocytin and confirmed as excitatory by negative immunoreactivity for GAD67. GAD67 and merged...
UNIVERSITY OF COPENHAGEN – THE FACULTY OF HEALTH AND MEDICAL SCIENCES Parkinson’s Disease develops if a certain anti-viral receptor and its protein in the brain, called the interferon-beta pathway, is not functioning correctly. That causes the pathway to be blocked, and as a result the brain cells gradually starts to die. Scientists and private companies...
by University of Copenhagen Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Parkinson’s Disease develops if a certain anti-viral receptor and its protein in the brain, called the interferon-beta pathway, is not functioning correctly. That causes the pathway to be blocked, and as a...
by Rush University Medical Center Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia Potential new treatments for Parkinson’s disease developed by researchers at Rush University Medical Center have shown success in slowing progression of the disease in mice. In a study published in Nature Communications, Rush researchers found that...
by Jennifer Michalowski, University of Utah Health Sciences Figure 1. Activity of A-443654 in qHTS assays. (a) Molecular structure of A-443654. (b) Relative luciferase activity in SNCA-Luc (IC50=251 nM, triangles), CMV-luc (open circles) and viability (squares) of SNCA-luc cells measured after 24 hrs of treatment with A-443654 at the indicated doses. Credit: DOI: 10.1016/j.jbc.2021.101191 University of...
A team from National Yang Ming Chiao Tung University has developed a foot-pressure-sensing insole to detect Parkinson’s disease. Using tiny Raspberry Pi computers, they managed to create something discreet that can monitor people as they walk around in their own shoes.Video: Team Forelook What is Parkinson’s disease? Parkinson’s disease is a neurodegenerative disorder that mostly affects...
by University of Connecticut Credit: Yulan Xiong Mutations in a protein known to cause Parkinson’s Disease derange transportation in and out of brain cells, reports a team of UConn Health researchers in the 27 July issue of Science Signaling. The toxic traffic jams that result eventually lead to certain brain cell death and the characteristic symptoms of Parkinson’s. “We...
By Michael Irving September 07, 2021 Tiny lab-grown mini-brains have now been induced to show pathology features of Parkinson’s disease Associate Professor Hyunsoo Shawn Je, Duke-NUS Medical School. To help us crack the complex puzzle that is our own brains, scientists have been growing miniature versions in the lab. Now, a team in Singapore has...
by University of Westminster Credit: Pixabay/CC0 Public Domain A new study led by Dr. Beth Parkin, senior lecturer in psychology from the Cognitive Neuroscience Group at the University of Westminster, has discovered that a substantial proportion of people with Parkinson’s disease have precise deficits when learning from instructions, and these problems are associated with differences in...
by Gladstone Institutes Gladstone researchers, including Ken Nakamura (left), Zak Doric (center), and Huihui Li (right), tracked mitochondria inside neurons and uncovered a new recycling pathway that may be linked to Parkinson’s disease. Credit: Michael Short/Gladstone Institutes Scientists have long known that living cells are master recyclers, constantly breaking down old parts and building them back up...
