(HealthDay)—There are many unanswered questions about the safety and effectiveness of a drug used to combat hallucinations and delusions in Parkinson disease patients, says a report from a drug safety group. The nonprofit Institute for Safe Medication Practices (ISMP) called for Nuplazid to have stronger warnings on its label for patients and their families, CNNreported. The U.S. Food and Drug Administration deemed the drug a “breakthrough” medication and gave it an expedited...
Tag: <span>Parkinson’s disease</span>
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Researchers explore link between metal exposure and Parkinson’s symptoms
A new study from Iowa State University biomedical researchers illuminates the biological processes by which exposure to some metals can contribute to the onset of Parkinson’s-like symptoms. The study, published today in the peer-reviewed journal Science Signaling, focuses on the metal manganese, which has a range of industrial uses as an alloy. Anumantha Kanthasamy, a...
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Scientists report new modeling of brain signaling
The release of neurotransmitters and hormones in the body is tightly controlled by complex protein machinery embedded in cell membranes. Manipulating that machinery with drugs could improve treatment of disorders ranging from diabetes to Parkinson’s disease. Progress has been slow, however, because of the lack of an animal model to test the effects of potential...
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Can we repair the brain? The promise of stem cell technologies for treating Parkinson’s disease
Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson’s disease (PD) in future. Writing in a special supplement to the Journal of Parkinson’s Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges, of stem cell treatment. The most common PD treatment today is based on enhancing the activity of...
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Promise of stem cell technologies for treating Parkinson’s disease
Cell replacement may play an increasing role in alleviating the motor symptoms of Parkinson’s disease (PD) in future. Writing in a special supplement to the Journal of Parkinson’s Disease, experts describe how newly developed stem cell technologies could be used to treat the disease and discuss the great promise, as well as the significant challenges,...
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Personalised treatments for Parkinson’s disease
Scientists at Cardiff University are helping to bring personalised treatments for Parkinson’s disease closer to the clinic, thanks to a major investment of over £50,000 from American charity, The Summit for Stem Cell Foundation. Working in partnership with Professor Jeanne Loring of the Scripps Research Institute, Cardiff University’s Dr Mariah Lelos is testing the potential...
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Study implicates hyperactive immune system in aging brain disorders
In a study of fruit flies, NIH scientists suggested that the body’s immune system may play a critical role in the damage caused by aging brain disorders. The results are based on experiments in which the researchers altered the activity of Cdk5, a gene that preclinical studies have suggested is important for early brain development...
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Singing may reduce stress, improve motor function for people with Parkinson’s disease
Elizabeth Stegemöller leads a singing group for people with Parkinson’s disease. Her latest research shows singing can lower stress and improve motor symptoms. Credit: Iowa State University Singing may provide benefits beyond improving respiratory and swallow control in people with Parkinson’s disease, according to new data from Iowa State University researchers. The results from the...
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Parkinson’s Disease at a cellular level: Recent research
Parkinson’s disease affects around one million people in the US and between seven and ten million worldwide. In people with Parkinson’s disease, the neurons in the brain that produce dopamine die off. Dopamine is a neurotransmitter, a chemical that helps send messages in the brain. It is involved in many functions such as movement, reward,...
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Cooling ‘brains on fire’ to treat Parkinson’s
A promising new therapy to stop Parkinson’s disease in its tracks has been developed at The University of Queensland. UQ Faculty of Medicine researcher Associate Professor Trent Woodruff said the team found that a small molecule, MCC950, stopped the development of Parkinson’s in several animal models. The NLRP3 inflammasome (green) is expressed by immune cells...