by Shinshu University Patient with Parkinsonian gait disturbances seeking brain stimulation to improve walking dynamics. A sinusoidal waveform was utilized to delivery electrical current on the cerebellum. The initiation of each current coincided with the moment of heel contact on the affected side during a self-paced four minutes gait. Credit: Ippei Nojima Gait-related disturbances adversely...
by Anna Zarra Aldrich, University of Connecticut Proper regulation of LRRK2 levels is important for Parkinson’s disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate precursor AICAr regulate LRRK2 mRNA levels via an mRNA decay pathway. AICAr suppresses LRRK2 expression and can rescue LRRK2-induced dopaminergic neurodegeneration and neuroinflammation in PD animal models. Credit: The EMBO...
by Universita Cattolica del Sacro Cuore Credit: CC0 Public Domain Neuroscientists from the Faculty of Medicine of the Catholic University, Rome Campus, and the A. Gemelli IRCCS Polyclinic Foundation have found that intensive exercise could slow the course of Parkinson’s disease. The finding could pave the way for new non-drug approaches. The study, “Intensive exercise ameliorates motor...
by Ecole Polytechnique Federale de Lausanne Early hallucinations in Parkinson’s disease are associated with frontal cognitive decline (triangles), and preceded by specific frontal neural oscillation (theta frequency band). Credit: EPFL / Bernasconi. Have you ever felt the strong sensation that someone is behind you, so intense that you turn around, only to see that no-one is...
by Eric W. Dolan June 26, 2023 in Mental Health [Subscribe to PsyPost Premium to enjoy an ad-free experience! Click here to sign up.] New research suggests that drugs used to treat insulin resistance could potentially help in treating neurodegenerative disorders like Parkinson’s disease. The study found that semaglutide, a compound found in medications like...
by Walter and Eliza Hall Institute of Medical Research Credit: Molecular Cell (2023). DOI: 10.1016/j.molcel.2023.04.021 While mitochondria play a crucial role in producing the energy our cells need to carry out their various functions, when damaged, they can have profound effects on cellular function and contribute to the development of various diseases. Broken-down mitochondria are usually removed and recycled through a...
JUNE 6TH, 2023 CONN HASTINGS DIAGNOSTICS, MEDICINE, NEUROLOGY Scientists at Purdue University have developed a urine test for early-stage Parkinson’s disease. The technology involves isolating extracellular vesicles of neural origin from urine samples and then assessing the proteins within the vesicles to detect biomarkers of the disease. The researchers have called their technology “EVtrap” (Extracellular Vesicles total recovery...
by Cell Press Photo of iPSCs-derived Motor neurons derived from an ALS patient. Credit: Morimoto et al/Cell Stem Cell Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles. There is no cure, and current treatments focus on reducing symptoms...
Megan Brooks March 01, 2023 Adverse childhood experiences (ACEs) are associated with increased motor and nonmotor symptoms of Parkinson’s disease (PD) and reduced quality of life (QOL), new research shows. Results of the first study to evaluate the relationship between childhood trauma and PD investigators found that the relationship appears to be dose dependent. Patients with PD who reported more than...
by Justin Jackson, Medical Xpress Credit: Unsplash/CC0 Public Domain Research led by Kosin University College of Medicine in Korea has found a correlation between patients with rheumatoid arthritis and Parkinson’s disease. In their paper published in JAMA Neurology, researchers found a significantly higher risk of Parkinson’s disease (PD) in patients with rheumatoid arthritis (RA). In a cohort study of...
