by Brigham and Women’s Hospital Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia The human brain is lipid rich. Lipids and fatty acids contribute to many important cellular processes. Alpha-synuclein—a protein that plays a critical role in Parkinson’s disease (PD)—is known to interact...
by Dirk Hoffman, University at Buffalo Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia A new study led by a researcher in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo has important implications for developing future treatments for Parkinson’s...
by Brigham and Women’s Hospital A graphic depicts the “two faces of alpha-synuclein” and the transition from normal states (upper, organized molecular machines on a well-defined grid) to pathologic states in which there is membrane disruption, altered protein interactions and localization (lower, chaotic, disrupted machines, darker tone). Credit: Gergana Petrova. One of the hallmarks of...
by University of Birmingham Credit: Pixabay/CC0 Public Domain Older adults who start to experience bad dreams or nightmares could be exhibiting the earliest signs of Parkinson’s disease, say researchers at the University of Birmingham. A new study, published in eClinicalMedicine, showed that in a cohort of older men, individuals experiencing frequent bad dreams were twice as...
by Kobe University Figure 1: Disease onset and changes in P450 expression. Credit: Kobe University Researchers at Kobe University and Hiroshima University have successfully developed a biomarker that will enable Parkinson’s disease to be rapidly and inexpensively diagnosed from blood serum samples. It is hoped that being able to diagnose the disease faster will also lead...
In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson’s disease. Specifically, the researchers found that a protein dubbed “STING” responds to clean-up signals in brain cells...
by University of Cambridge Locus coeruleus as observed in a 7T MRI scanner. Credit: University of Cambridge Ultra-powerful 7T MRI scanners could be used to help identify those patients with Parkinson’s disease and similar conditions who are most likely to benefit from new treatments for previously-untreatable symptoms, say scientists. Both Parkinson’s disease and a related...
by Richard Harth, Arizona State University Credit: Shireen Dooling for the Biodesign Institute at Arizona State University Neurodegenerative diseases damage and destroy neurons, ravaging both mental and physical health. Parkinson’s disease, which affects over 10 million people worldwide, is no exception. The most obvious symptoms of Parkinson’s disease arise after the illness damages a specific...
by New York Stem Cell Foundation Immunohistochemistry for alpha-synuclein showing positive staining (brown) of an intraneural Lewy-body in the Substantia nigra in Parkinson’s disease. Credit: Wikipedia A study published today in Nature Communications unveils a new platform for discovering cellular signatures of disease that integrates robotic systems for studying patient cells with artificial intelligence methods for image...
Parkinson’s disease affects the nervous system. The disease damages or kills nerves in the brain, which results in muscle stiffness, tremors, and other symptoms. Females with Parkinson’s disease may report different symptoms and receive a lower quality of care compared with males. Sex and gender exist on spectrums. This article will use the terms “male,”...
