by California NanoSystems Institute Disruptions in the fission of mitochondria, the structures within cells that make energy, are behind a host of other ailments, including cancer, diabetes and heart disease. Credit: National Institutes of Health As scientists work toward finding a cure for Parkinson’s disease, one line of research that has emerged focuses on mitochondria,...
by La Jolla Institute for Immunology Parkinson’s disease is not usually seen as an autoimmune disease. Credit: Leterrier, NeuroCyto Lab, INP, Marseille, France Scientists at La Jolla Institute for Immunology (LJI) have found that people with Parkinson’s disease have a clear “genetic signature” of the disease in their memory T cells. The scientists hope that...
UNIVERSITÉ DE GENÈVE IMAGE: BIOLOGISTS HAVE CREATED MUTANTS OF THE FER2 HOMOLOG IN MOUSE DOPAMINE NEURONS. CREDIT: (C) ADOBE STOCK Parkinson’s disease is a neurodegenerative disorder characterized by the destruction of a specific population of neurons: the dopaminergic neurons. The degeneration of these neurons prevents the transmission of signals controlling specific muscle movements and leads...
by IOS Press Confocal microscope study of p-syn deposits in a dermal arteriole of a patient with Parkinson disease (A) and a patient with CBS (B). In both cases, most of the PGP9.5-stained fibers demonstrate the presence of p-syn as neuritic inclusions (arrowheads) shown by the merged image (scalebar 50 μM). Credit: Dr. Alex Incensi...
by The Scripps Research Institute A team at Scripps Research reveals details into how Parkinson’s disease and Lewy body dementia spread in the brain. In neurons, the LC3 protein (green) and LAMP1 protein (red) fuse together into autolysomes (yellow) where autophagy, a cellular mechanism for clearing misfolded proteins, occurs. The prominence of green shows that...
AMERICAN CHEMICAL SOCIETY A couple of years ago, a woman named Joy Milne made headlines when scientists discovered that she could “smell” Parkinson’s disease (PD) on people with the neurodegenerative disorder. Since then, researchers have been trying to build devices that could diagnose PD through odor compounds on the skin. Now, researchers reporting in ACS Omega have...
by Kathy Keatley Garvey, UC Davis This is Sophora flavescens. A compound from this plant reduce neuroinflammation in an animal model with Parkinson’s disease. Credit: Wikipedia/CC0 Public Domain A natural product from the dried root of a pea-family plant, potentially combined with an enzyme inhibitor discovered in the Bruce Hammock laboratory at the University of...
In a small lab decorated with a poster of colorful MRI brain scans, Elizabeth Stegemoller hits a stopwatch to record how long a participant in her study can sustain the vowel sound “ah” before taking a breath. They run through this a few times before Stegemoller moves on to measure the participant’s range of pitch...
by American Heart Association Credit: Pixabay/CC0 Public Domain People who have had a heart attack may be slightly less likely than people in the general population to develop Parkinson’s disease later in life, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart...
by Pennsylvania State University Credit: Pixabay/CC0 Public Domain People with Parkinson’s disease who eat more flavonoids—compounds found in richly colored foods like berries, cocoa, and red wine—may have a lower mortality risk than those who don’t, according to a new study. Specifically, the researchers found that when people who had already been diagnosed with Parkinson’s...
