By Rich Haridy January 11, 2023 Ambroxol, an ingredient in common cough medicines, may be useful in treating Parkinson’s disease Depositphotos A landmark Phase 3 clinical trial is beginning in the UK, testing whether a common cough medicine can be used to treat Parkinson’s disease. Early studies indicate the 50-year-old drug can cross into the...
Kelli Whitlock Burton April 11, 2022 An experimental drug that combines fixed doses of extended-release (ER) formulations of existing medications can significantly reduce symptoms in patients with untreated early-stage Parkinson’s disease (PD), new research suggests. Results from a phase 3 trial of P2B001, a combination of pramipexole and rasagiline at currently unavailable low doses, showed...
by Olivia Miller, University of Kent Professor David Wilkinson. Credit: University of Kent Some of the most troubling features of Parkinson’s disease can be reduced by gentle stimulation of the balance organs via the application of electric or thermal currents to nearby parts of the head. This observation, made by Professor David Wilkinson at the...
by Experimental Biology A probiotic was engineered to endogenously produce L-DOPA from tyrosine using recombinant 4-hydrophenylacetate 3-monooxygenase and FAD reductase genes. The L-DOPA live-biotherapeutic is pre-activated and orally administered. Tests of the new drug delivery approach reveal steady-state plasma L-DOPA levels and brain dopamine levels in pre-clinical animal models. Credit: Piyush Padhi, University of Georgia...
UNIVERSITAT AUTONOMA DE BARCELONA IMAGE: NANOENCAPSULATION OF DOPAMINE CREDIT: ICN2/IBB-UAB Parkinson’s disease (PD) is a common neurodegenerative disorder caused by the death of dopaminergic neurons in a part of the brain (known as substantia nigra pars compacta), which leads to a deficit of dopamine (DA), one of the main neurotransmitters active in the central nervous...
PETER DOCKRILL A drug first discovered over 50 years ago and long used as a medicine for coughs and respiratory illnesses appears to show promise in treating a very different kind of sickness: Parkinson’s disease. Ambroxol, an active ingredient in cough mixtures since the 1970s, has been investigated in recent years for its apparent potential...
Researchers asked 36 healthy adults to imagine moving their left hand Half were shown a display if they were activating the right parts of their brains The others were given false readings as a placebo to confirm the game’s impact Activity in the brains of those who weren’t given the placebo was stronger By TIM COLLINS FOR...
Ball-and-stick model of the dopamine molecule, a neurotransmitter that affects the brain’s reward and pleasure centers. Three researchers at The University of Alabama are part of work that is leading to a new direction for drug discovery in the quest to treat Parkinson’s disease. Findings from the study are published today in the journal Nature...
