by FAPESP Credit: Unsplash/CC0 Public DomainParkinson’s disease patients who experience freezing of gait (a sudden inability to initiate or continue movement, often resulting in a fall) wake up several times during the night, feel sleepy during the day, and have REM sleep behavior disorder. Rapid eye movement (REM) sleep plays a role in the maintenance of...
by Arizona State University A new study highlights the role of misfolded tau proteins in the genesis and trajectory of Parkinson’s disease. Credit: Jason Drees for the Biodesign Institute at Arizona State UniversityParkinson’s disease, the second most common type of progressive dementia after Alzheimer’s disease, affects nearly 1 million people in the U.S. and an estimated...
People with Parkinson’s have fewer tremors when they receive rhythmic physical stimulation—so a UK startup has created a coin-sized vibrating device to help patients move more easily. PHOTOGRAPH: CHARCO NEUROTECH IN 2015, LUCY Jung was a young industrial designer working on assistive devices for stroke victims, people with multiple sclerosis, and those with other conditions...
by University of Barcelona Credit: Journal of Clinical Investigation Insight (2024). DOI: 10.1172/jci.insight.163359. https://insight.jci.org/articles/view/163359Parkinson’s disease is one of the most common diseases affecting the motor and nervous system. It has no treatment yet, and the pathology causes a deterioration of motor skills due to dopaminergic neuronal death, the neurons that synthesize dopamine, which is a brain...
The metabolic product of an anticancer drug demonstrates potential activity in neurons derived from Parkinson’s patients and a synergistic action, together with the original drug, in prostate cancer cellsPeer-Reviewed Publication SPANISH NATIONAL RESEARCH COUNCIL (CSIC) L’Hospitalet de Llobregat, February 8th, 2024. Once they enter the body, drugs, apart from carrying out their therapeutic function, are...
by University Health Network The model emphasizes the important interactions between three biological factors contributing to Parkinson’s: the presence of pathologic α-synuclein in the brain, evidence of neurodegeneration and the presence of gene variants. Credit: University Health NetworkAn international research team led by Krembil Brain Institute Neurologist and Senior Scientist, Dr. Anthony Lang, has proposed a...
by Marina Romero-Ramos, Aarhus University Differential expression of p62/SQSTM1 autophagy marker in the substantia nigra, piriform cortex and amygdala after α-syn PFF injection. Bar graphs with individual points illustrate the total number of p62+ cells in the SN at a 1 and d 6 months p.i. b Representative images of p62/SQSTM1 immunostaining in α-syn PFF animals...
by Justin Jackson , Medical Xpress Pixabay/CC0 Public DomainResearchers at the Scripps Research Institute, Florida, have developed a new method to counteract α-synuclein protein levels by targeting the mRNA that forms them. The strategy unlocks many research doors with potential therapeutic approaches for addressing neurodegenerative diseases. In a paper, “Decreasing the intrinsically disordered protein α-synuclein...
by University of Southern California Credit: Unsplash/CC0 Public DomainA previously unidentified genetic mutation in a small protein provides significant protection against Parkinson’s disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study. The variant, located in a mitochondrial microprotein dubbed SHLP2, was found to be...
by University of California, Los Angeles Credit: Pixabay/CC0 Public Domain As Parkinson’s disease diagnoses continue to rise in the U.S., limited patient access to movement disorder specialists means the job of delivering the often-devastating, life-changing news falls on primary care physicians or community neurologists who may not have the necessary expertise for this sensitive task. A...
