by Foundation for Research and Technology – Hellas Graphical abstract. Credit: Foundation for Research and Technology – Hellas International scientific collaboration between Researchers at the Institute of Molecular Biology & Biotechnology of FORTH, and Scientists at the National and Kapodistrian University of Athens and the University of Oslo, in Norway, has uncovered the novel role of the DNA base excision...
by Karolinska Institute Credit: CC0 Public Domain In the search for new ways to treat the incurable eye disease glaucoma, researchers at Karolinska Institute and St. Erik Eye Hospital have discovered more clues as to its pathogenesis. A new study shows how metabolic disturbance of the neurons coincide with raised pressure in the eye. In animal...
by Nagoya University Under normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functional machinery is impaired, the splicing ratio of MAPT exon 10+/exon 10- is increased, which in turn results in an increased 4R-Tau/3R-Tau ratio. The findings...
by Sanford Burnham Prebys Medical Discovery Institute Discovery Institute, gestures to experimental assays that test for compounds that may treat COVID-19. Credit: Sanford Burnham Prebys Medical Discovery Institute A Nature study authored by a global team of scientists and led by Sumit Chanda, Ph.D., professor at Sanford Burnham Prebys Medical Discovery Institute, has identified 21...
by Sanford Burnham Prebys Medical Discovery Institute Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a next-generation drug called Ciapavir (SBI-0953294) that is effective at reactivating dormant human immunodeficiency virus (HIV). The research, published in Cell Reports Medicine, aims to create a functional HIV cure by activating and then eliminating all pockets of...
Reviewed by Emily Henderson, B.Sc. ANCA-associated vasculitis (AAV) is a systemic disease involving the formation of special autoantibodies (so-called anti-neutrophil cytoplasmic antibodies/ANCA) and vascular inflammation. There are several diseases associated with involvement of the kidneys, lungs, upper respiratory tract, heart, skin and the nervous system; potentially life-threatening courses of disease are also possible. Immunosuppressive therapy...
UNIVERSITY OF TURKU Researchers from the Turku Bioscience Centre in Finland have found changes in molecules in the blood that might be new markers of type 1 diabetes. New findings may help understand the early pathogenesis of the disease. Finland has the highest recorded incidence of type 1 diabetes in children younger than 15 years, and the global prevalence...
by Jeff Hansen, University of Alabama at Birmingham Multiple sclerosis is an autoimmune disease that damages the insulating sheaths of nerve cells of the central nervous system. People with the disease can lose vision, suffer weak limbs, show degenerative symptoms and exhibit impaired cognition. While multiple sclerosis has 17 approved therapies to modify the disease, none is able to halt disease...
