by Tokyo University of Science Mouse model of familial colorectal adenomatosis (ApcMin) showing significantly fewer colonic polyps in Dectin-1-deficient (Clec7a–/–) mice; B. Polyps show reduced expression of PGE2 synthase (Cox2). In vitro, Cox2 expression is induced in myeloid cells by curdlan—a high-molecular-weight β-glucan—and conversely inhibited by laminarin—a low-molecular-weight β-glucan; C. Increased IL-22BP expression in Clec7a–/– mice;...
