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Cleveland Clinic-led trial shows drug effective in nearly 80% of patients with hypertrophic cardiomyopathy

CLEVELAND CLINIC EMBARGOED UNTIL 9:30A.M. ET., Saturday, April 2nd, 2022, Cleveland: Findings from a Cleveland Clinic-led clinical trial showed that the use of an experimental drug in severely symptomatic, hypertrophic cardiomyopathy patients significantly reduced the need for invasive procedures.   The trial evaluated whether the drug, mavacamten, could be used as an alternative to heart surgery...

Study suggests additional COVID-19 vaccine doses for immunocompromised patients
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Study suggests additional COVID-19 vaccine doses for immunocompromised patients

by British Medical Journal Credit: Pixabay/CC0 Public Domain Additional doses of COVID-19 vaccine are recommended for immunocompromised patients, especially for organ transplant recipients who are least able to make antibodies to fight off coronavirus, say experts in The BMJ today. The findings reinforce the importance of additional doses of COVID-19 vaccine to protect people with a weakened...

FDA expands approval of jardiance for patients with heart failure
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FDA expands approval of jardiance for patients with heart failure

Approval for Jardiance (empagliflozin) has been expanded to reduce the risk for cardiovascular death and hospitalization for heart failure in adults, the U.S. Food and Drug Administration announced Thursday. Jardiance previously received approval in 2014 as a supplement to diet and exercise for improving glucose control in adults with type 2 diabetes. The drug is...

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New tool may improve detection of esophageal cancer in patients with Barrett’s esophagus

UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS On a mission to increase early detection of esophageal cancer, University of Colorado (CU) Cancer Center member Sachin Wani, MD, is leading a study to see if a novel diagnostic platform can help endoscopists better identify the disease in patients with a condition called Barrett’s esophagus. Barrett’s esophagus, a...

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Belzutifan offers hope for patients with von Hippel-Lindau disease

Patients with von Hippel–Lindau disease, a genetic condition brought on by a mutation in the VHL gene that predisposes the carrier to developing different kinds of tumors, have a high incidence of cancers, like kidney cancer. This is because of an inactive VHL gene that leads to hypoxia signaling, a condition that results from an imbalance...

COVID-19 : Measuring viral RNA to predict which patients will die
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COVID-19 : Measuring viral RNA to predict which patients will die

by University of Montreal Colorized scanning electron micrograph of a cell (blue) heavily infected with SARS-CoV-2 virus particles (red), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID The amount of a SARS-CoV-2 genetic material—viral RNA—in the blood is a reliable indicator in detecting...

Study: Diabetes complications affect patients of different ethnic groups very unevenly
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Study: Diabetes complications affect patients of different ethnic groups very unevenly

by Asociacion RUVID Graphical abstract. Credit: DOI: 10.1007/s00125-021-05554-9 Professor and researcher of the Faculty of Nursing and Podiatry of the UV, Yasmín Ezzatvar, together with researchers from other centers, concludes that the racial or ethnic group of patients with type 1 and 2 diabetes mellitus influences the prognosis of the disease, due to differences in...

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Frontrunner target for Parkinson’s Disease may only be relevant for small fraction of patients

UNIVERSITY OF COPENHAGEN – THE FACULTY OF HEALTH AND MEDICAL SCIENCES Parkinson’s Disease develops if a certain anti-viral receptor and its protein in the brain, called the interferon-beta pathway, is not functioning correctly. That causes the pathway to be blocked, and as a result the brain cells gradually starts to die. Scientists and private companies...

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Do family members understand the end-of-life wishes of patients on chronic dialysis?

by  American Society of Nephrology Patients with kidney failure who are on long-term dialysis often rely on family members or friends to make critical treatment decisions towards the end of life. A study in CJASN examines whether such close contacts have a good understanding of these patients’ wishes. The study conducted by Fahad Saeed, MD (University...

Powerful new ovarian cancer treatments may benefit more patients
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Powerful new ovarian cancer treatments may benefit more patients

by  Walter and Eliza Hall Institute of Medical Research Cancer cell during cell division. Credit: National Institutes of Health WEHI researchers have made a discovery that could help more Australian women with ovarian cancer gain access to game-changing cancer treatments called PARP inhibitors. The research team found tumors from some ovarian cancer patients had changes that silenced a gene involved in DNA repair...