by Elana Gotkine For patients with moderate-to-severe plaque psoriasis, the interleukin-23-receptor antagonist peptide JNJ-77242113 shows greater efficacy than placebo, according to a study published in the Feb. 8 issue of the New England Journal of Medicine. Robert Bissonnette, M.D., from Innovaderm Research in Montreal, and colleagues conducted a phase 2 dose-finding trial involving 255 patients...
Tag: <span>peptide</span>
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Scientists develop a peptide that targets lung tumors and delivers therapeutics inside cells
by SRI International Monomeric and tetrameric MGS4 have similar binding, internalization and subcellular location. a, Binding and internalization of tetrameric MGS4_V1 and monomeric MGS4_V2 on live H1299 cells in culture. Cells were incubated with the peptide conjugated to streptavidin-phycoerythrin for 1 h at 37 °C. Non-internalized peptide was removed and the cells were analyzed by flow cytometry....
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Gut microbe peptide implicated in triggering type 1 diabetes
by Joslin Diabetes Center Credit: Pixabay/CC0 Public Domain In type 1 diabetes, the body develops immune cells that target pancreatic beta cells, which play a critical role in the production and secretion of insulin. One of the earliest targets of this immune response is a specific sequence of amino acids, or peptide, within the insulin...
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Peptide with anti-obesity action is successfully tested in animal trial
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: CHEMICAL STRUCTURE OF PEP19 CREDIT: RESEARCHERS’ ARCHIVE A study conducted at the University of São Paulo (USP) in Brazil shows that the synthetic molecule Pep19 acts on the endocannabinoid system, which helps regulate and balance key metabolic functions, such as appetite, fat breakdown (lipolysis),...
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Peptide delays melanoma growth in animal trials
by Luciana Constantino, FAPESP Time-lapse phase images of melanoma B16F10-Nex2 cells treated with Rb4 and Scr-Rb4. (A) Panels are representative fields of B16F10-Nex2 cells after control, Rb4 or Scr-Rb4 treatment for 1, 6, 12 and 24 h of incubation. Loss of morphology and no replication was observed for Rb4-treated cells. (B) Representative panels of B16F10-Nex2 cells...
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Scientists think a peptide could stop, reverse damage to nerve cells
by Carrie Foust, University of Illinois at Chicago Stem cell-derived neurons created in the Regenerative Medicine and Disability Laboratory at UIC allow researchers to see how certain drugs or gene therapies can work in human nerve cells. Credit: Xue-Jun Li/UIC Researchers at the University of Illinois Chicago found promising results in their search for a...
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Jynigsaw-shaped peptide solves tissue regeneration puzzle
by Tokyo Medical and Dental University (Left) Jigsaw-shaped hydrophobic surface is the key structure forming nanofiber through β-sheet assembly. (Right) JigSAP-tagged VEGF (VEGF-JigSAP) is efficiently incorporated into and released from JigSAP hydrogels. Credit: Center for Brain Integration Research, TMDU Recreating native physiological processes in manmade materials imitating the biological structures involved in wound healing has...
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U. Iowa team is developing new delivery tools for gene editing
Engineered peptides provide efficient, non-toxic delivery of gene-editing proteins to airway cells UNIVERSITY OF IOWA HEALTH CARE News of advances in gene-editing technology raises the prospect of actually using this approach to treat disease in patients. But one of the hurdles that remains is how to deliver these tools to the right cells in the patients safely and efficiently. Scientists led by University of Iowa researcher Paul...
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Could targeting this heart hormone help control blood pressure?
By Catharine Paddock PhD Fact checked by Paula Field Recent insights into a hormone released by muscle cells could lead to improved ways to treat high blood pressure. When the hormone, which has the name atrial natriuretic peptide (ANP), enters the bloodstream, it lowers blood pressure by triggering blood vessel dilation and excretion of sodium in...
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What are Peptide Aptamers?
Peptide aptamers are small, artificial polypeptides, which bind to target proteins in a highly specific manner, similar to antibodies. These proteins can occur naturally or they may be artificially created. What are Aptamers? Aptamers were first used in research following their discovery in the 1990’s when Tuerk and Gold developed a methodology to select for...
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