by Karolinska Institutet Engineering cells to produce EVs decorated with an antibody-binding moiety specific for the Fc domain. Credit: Nature Biomedical Engineering (2024). DOI: 10.1038/s41551-024-01214-6Researchers at Karolinska Institutet in Sweden have succeeded in delivering targeted cancer treatment via small membrane bubbles that our cells use to communicate. A study, “Antibody-displaying extracellular vesicles for targeted cancer...
Tag: <span>pharmaceutical</span>
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First Test of Drug in a Patient with Life-Threatening Blood Clotting Disorder – pharmaceutical
Results from this first use of the drug for this condition warrants testing the drug in a clinical trial.News Published: May 20, 2024 | Original story from Massachusetts General Hospital Read time: 2 minutesA team led by investigators from Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, used a new...
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Diet and Exercise in a Pill Are Real: How Mimetics Work – pharmaceutical
If couch-potato lab mice had beach-body dreams and if they could speak, they might tell you they’re thrilled by advances in the science of exercise and calorie-restriction (CR) mimetics. In recent studies conducted at research centers across the United States, mice have chowed down, fattened up, exercised only if they felt like it, and still...
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Signalling research waves red flag for commercial drug target candidate
by Babraham Institute Credit: Unsplash/CC0 Public Domain Researchers at the Babraham Institute have used their understanding of cellular signaling to highlight a pitfall in an emerging treatment for cancer and inflammation. A new review just published in Biochemical Society Transactions summarizes the researchers’ current knowledge, which includes details of their research published in Nature Communicationsearlier this year....
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Protein discovery could improve type 2 diabetes treatment
by University of Melbourne A world first discovery of how a protein works in the liver could lead to a more effective type 2 diabetes drug. The University of Melbourne-led study found that the SMOC1 protein, which is naturally produced by the liver, can decrease blood glucose levels. An engineered form of SMOC1 could therefore...
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Stomach SIDT1 mediates dietary microRNA absorption: ending of the 10-year debate
NANJING UNIVERSITY SCHOOL OF LIFE SCIENCES In a new study published in Cell Research, Chen-Yu Zhang’s group at Nanjing University School of Life Sciences, China, reports that SIDT1 in the mammalian stomach mediates host uptake of dietary and orally administered microRNAs (miRNAs), thus exerting biological functions in the host. In previous studies, Chen-Yu Zhang’s group...
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MSG promotes significant sodium reduction and enjoyment of better-for-you foods, according to new study
ITASCA, Illinois – A new study published in the Journal of Food Science suggests monosodium glutamate (MSG) can be used to significantly reduce sodium while also promoting the enjoyment of better-for-you foods like grains and vegetables. In the study, supported by Ajinomoto Co., Inc., participants evaluated four different recipes in which sodium was reduced by...
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Gut microbiome translates stress into sickle cell crises
ALBERT EINSTEIN COLLEGE OF MEDICINE July 30, 2020–(BRONX, NY)–A new study shows how chronic psychological stress leads to painful vessel-clogging episodes–the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations. The findings, made in mice, show that the gut microbiome plays a key role in triggering those episodes and reveals possible...
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Dietary guidelines advisory committee reinforces need for increased choline intake
Dietary guidelines advisory committee reinforces need for increased choline intake Vulnerable populations, including infants, toddlers, pregnant and lactating women, are at greatest risk for choline deficiency FOODMINDS LLC NEW HAMPTON, N.Y., July 20, 2020 — On Wednesday, July 15, 2020, the Dietary Guidelines Advisory Committee (DGAC or Committee) – a group comprised of 20 nationally...
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Single-dose flu drug can reduce spread within households, study finds
UNIVERSITY OF VIRGINIA HEALTH SYSTEM “THIS TRIAL ESTABLISHED THAT BALOXAVIR, IF TAKEN WITHIN A DAY OR SO AFTER EXPOSURE, IS HIGHLY EFFECTIVE FOR PREVENTING INFLUENZA ILLNESS IN HOUSEHOLDS, A HIGH-RISK SETTING FOR VIRUS TRANSMISSION, ” SAID… view more CREDIT: DAN ADDISON | UVA COMMUNICATIONS A single dose of the flu drug baloxavir marboxil can reduce...