Inhibiting ceramide accumulation in retina protects photoreceptors, improves vision. Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately...
Tag: <span>pharmacological treatment</span>
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Researchers discover cause, develop pharmacological treatment for reducing retinitis pigmentosa vision loss
by University of California, Irvine “AdipoR1 is one of the principal enzymes that regulate ceramide content in the eye,” says first and co-corresponding author Dominik Lewandowski, Ph.D., postdoctoral scholar at the UCI School of Medicine. “Ceramide accumulation is detrimental for the retina and has been associated with non-syndromic retinitis pigmentosa. Our study showed that this...