Heidelberg neurobiologists successfully test novel drug principle in a mouse model and in brain organoids of ALS patientsPeer-Reviewed Publication HEIDELBERG UNIVERSITY A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral...
Tag: <span>pharmacological</span>
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Virtual Reality distracts kids from pain
Researchers believe Virtual Reality (VR) headsets may help reduce children’s anxiety and their experience of pain when they undergo injections in an emergency department (ED). JCU’s Professor Cate Nagle was one of a team of scientists who examined the emerging technology. They analyzed four studies on the use of VR on patients 4 – 17...
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Scientists discover the switch that makes human brown fat burn energy
UNIVERSITY OF COPENHAGEN THE FACULTY OF HEALTH AND MEDICAL SCIENCES An international research team have discovered how to activate brown fat in humans, which may lead to new treatments for type 2 diabetes and obesity. The results of the collaboration between the Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS) and the Novo...
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The immune system: Knocked off balance
by Ludwig Maximilian University of Munich The immune system: Knocked off balanceInstead of protecting us, the immune system can sometimes go awry, as in the case of autoimmune diseases and allergies. An LMU team has dissected how mast cells regulate their calcium levels to keep the immune response under control. Credit: IMCES UK Essen/LMU Instead...
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Discovery of a novel drug candidate to develop effective treatments for brain disorders
The study published in Chem is fundamental to develop pharmacological drugs for the treatment of core symptoms in Down syndrome, autism and other brain disorders. Researchers aim to create a start-up company with the support of interested investors ISTITUTO ITALIANO DI TECNOLOGIA – IIT THE PROTEIN NKCC1 IS A TRANSPORTER OF IONS IN THE BRAIN;...
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How fear transforms into anxiety
by University of New Mexico A deadly coronavirus pandemic, economic instability and civil unrest menace the mental well-being of millions. Understanding how, in vulnerable people, fear from such frightening events evolves into lifelong anxiety, is critical for healing. A University of New Mexico research team led by Elaine L. Bearer, MD, Ph.D., the Harvey Family...
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Targeting Cellular Senescence as an Intervention in Aging
Senolytic drugs that destroy senescent cells, and later on, other senotherapies that either prevent senescence or block the senescence-associated secretory phenotype (SASP), are going to be very important in the treatment of aging. Senescent cells accumulate with age and are highly damaging to tissues. Via the SASP, even comparatively small numbers of lingering senescent cells...
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Electronic decision support tool reduces the risk of overmedication
by Johannes Angerer, Medical University of Vienna As the population ages, the prevalence of chronic disease increases. As a result, more drugs are prescribed. Around 25% of the population aged 65+ are affected by so-called “polypharmacy,” i.e., they regularly take at least five drugs. This results in an increased risk for drug interactions and adverse...
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Researchers discover a metabolic enzyme that spurs the growth and spread of liver cancer
by Sanford Burnham Prebys Medical Discovery Institute An enzyme that blocks the metabolic processes that contribute to the rapid growth and spread of liver cancer has been discovered, according to a study by researchers at Sanford Burnham Prebys and Weill Cornell Medicine. The findings, published in Cancer Cell, could spur development of new therapies for...
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Potential new treatment approach to fatal COVID-19
By Sally Robertson, B.Sc Researchers from the University of Colorado Anschutz Medical Campus and Pathways Bioscience in the United States have found that activating a transcription factor involved in oxidative stress regulation, antiviral activity, and inflammation may serve as a new treatment approach to coronavirus disease 2019 (COVID-19). The scientists propose that the antiviral and...
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