JUNE 3, 2024 by Karolinska Institutet a, Left, experimental design (partly created with Biorender.com) for single-cell RNA sequencing of HSPCs generated by single Vwf-tdTomato+ P-HSCs (n = 7) or Vwf-tdTomato− multi-HSCs. Right, mean (dots indicate individual mice) contribution to blood lineages. b, UMAP of LIN−cKIT+ cells replenished by single Vwf-tdTomato+ P-HSCs (blue; n = 7 mice, 2,290 cells) or...
Study results could point to new possibilities for personalised therapeutic approaches Peer-Reviewed Publication MEDICAL UNIVERSITY OF VIENNA Next to other complications, cirrhosis is also linked to abnormalities in haemostasis. However, the role of alterations in platelet function had previously been insufficiently investigated. Now, researchers at the Medical University of Vienna have shed light on the...
by Thamarasee Jeewandara , Phys.org Platelets transfected with mRNA using LNP can express exogenous protein. (A) Schematic describing the transfection of platelets using mRNA-LNP. (B) NanoLuc expression, measured as the relative luminescence units (RLU) per total protein, using various transfection agents (n = 3). (C and D) Representative flow cytometry plots and quantification of median...
by Julia Rinner, Technical University Munich Novel image-based flow cytometry enables the identification of cell aggregates and their components. a Scheme of a flow cytometry setup including a DHM and a microfluidic chip. The insert illustrates the applied principle of hydrodynamic focusing in two dimensions. b Study workflow: consisting of admission of patients to the hospital,...
by Isabella Backman, Yale University Fig. 1: Schematic representation of physiological and pathological roles of platelets. Credit: Nature Cardiovascular Research (2022). DOI: 10.1038/s44161-022-00021-z As a graduate student studying molecular cardiology at the Cleveland Clinic/Case Western Reserve University, John Hwa, MD, Ph.D., professor of medicine (cardiovascular medicine), found himself in an environment where many labs were studying platelets,...
UNIVERSITY OF MÜNSTER IMAGE: PLATELETS (RED) INTERACTING WITH REGULATORY T CELLS (YELLOW) IN THE BACTERIALLY INFLAMED LUNG TISSUE OF A MOUSE. RESEARCHERS EXAMINED THE LIVING TISSUE USING CONFOCAL FLUORESCENCE MICROSCOPY. CREDIT: ROSSAINT ET AL./JEXPMED 2021 Treating patients with acute respiratory failure is a constant challenge in intensive care medicine. In most cases, the underlying cause...
by Laval University Credit: CC0 Public Domain Platelets may play a key role in the development of lupus, according to a study published today by researchers at Université Laval and CHU de Québec-Université Laval Research Center. Extracellular DNA circulating in the blood of patients with lupus causes the inflammatory reaction associated with the disease. The researchers have shown that this DNA comes...
by Alan Mozes, Healthday Reporter The concern comes as 16- to 18-year-olds have emerged as one of the fastest-growing groups of blood donors nationwide. But this study of nearly 31,000 teens who gave blood more than once between 2016 and 2018 found that roughly one in 10 were already iron-deficient when they donated for the...
