by Harvard University Hofstenia miamia, three-banded panther worms. Credit: Mansi Srivastava and Kathleen Mazza-Curll Stem cells are a biological wonder. They can repair, restore, replace, and regenerate cells. In most animals and humans these cells are limited to regenerating only the cell type they are assigned to. So, hair stem cells will only make hair. Intestine...
by Indiana University School of Medicine Credit: Pixabay/CC0 Public Domain Researchers at Indiana University School of Medicine, in collaboration with the University of Alabama at Birmingham and five other institutions, are investigating novel regenerative medicine approaches to better manage vascular health complications from type 2 diabetes that could someday support blood vessel repair in the...
ALPHAMED PRESS IMAGE: LYLE ARMSTRONG, PH.D., PROFESSOR OF STEM CELL SCIENCES AT NEWCASTLE UNIVERSITY, UK, AND CORRESPONDING AUTHOR ON THE STUDY. CREDIT: ALPHAMED PRESS Durham, NC – A team led by researchers at Newcastle University, UK has successfully created a model of the cells found in the lungs that can be used to replicate how COVID-19 infects...
Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex, rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately 1,000 donors. Tens of thousands of tiny genetic variations...
by Tokyo Institute of Technology Human-induced pluripotent stem cells derived enterocyte-like cells exhibit P-gp- and BCRP-mediated efflux and cytochrome P450 (CYP3A4)-mediated metabolism. We concluded that hiPS cell-derived enterocyte-like cells can be used as a model for the evaluation of drug transport and metabolism studies in the human small intestine. Credit: Tokyo Tech A team of scientists...
by Oregon Health & Science University skin model in the lab that could be used to better understand and treat hair and skin disorders. Credit: Karl R. Koehler and Jiyoon Lee, Boston Children’s Hospital/Harvard Medical School. A new, hair-sprouting dollop of human skin created in the lab might one day help prevent hair loss. Organoids...
For decades, the enormous disease-curing potential of human stem cells has been thwarted by the inability to produce sufficient quantities of mature human cells in vivo — in a living organism. Now, a team led by University at Buffalo scientists has developed a method that dramatically ramps up the production of mature human cells in...
UNIVERSITY OF TURKU Focal adhesions are known as signalling platforms broadcasting the information of the biochemical and physical qualities of the extracellular matrix into intracellular signalling cascades. However, focal adhesions remain unstudied in the context of human pluripotent stem cells. The research group from the Turku Bioscience Centre at the University of Turku in Finland...
NEW YORK (GenomeWeb) – Researchers at the Hebrew University in Jerusalem, Israel have built a reference library of essential and growth-restriction genes in haploid human pluripotent stem cells (hPSCs) that they believe will reveal key aspects of cellular essentiality. In a study published yesterday in Nature, the researchers used a recently discovered group of haploid hPSCs to generate...
Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, participants discussed how the appearance of such variants can be monitored and minimized and, crucially, how their significance for the...
