Controlling dopamine signalling by targeting the histamine receptor has been shown to be a promising strategy for preventing the progression of Huntington’s disease in mice Scientists have described a potential new therapeutic strategy for slowing down early-stage Huntington’s disease in a new study published today in eLife. The research in mice indicates that targeting the...
Tag: <span>postdoctoral</span>
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What if we could design powerful drugs without unwanted side effects?
Psychedelics such as LSD and magic mushrooms have proven highly effective in treating depression and post-traumatic stress disorders, but medical use of these drugs is limited by the hallucinations they cause. “What if we could redesign drugs to keep their benefits while eliminating their unwanted side effects?” asks Ron Dror, an associate professor of computer...
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Mice with patchy coats lay bare how stem cells endure
Whether we like it or not, our hair continually grows. Its regenerative powers reside deep inside each hair follicle, in a cluster of dividing stem cells—some of which will specialize and eventually give rise to new hair while others will produce new stem cells. Scientists have delineated numerous mechanisms that guide stem cells toward particular...
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Genetic doppelgaengers: Emory research provides insight into two neurological puzzles
An international team led by Emory scientists has gained insight into the pathological mechanisms behind two devastating neurodegenerative diseases. The scientists compared the most common inherited form of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) with a rarer disease called spinocerebellar ataxia type 36 (SCA36). Both of the diseases are caused by abnormally expanded and...
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Continuity of buprenorphine treatment linked to significantly lower prescription opioid use and over
May 4, 2020 — A study at Columbia University Mailman School of Public Health found that long-term buprenorphine treatment is associated with improvements in health care outcomes. Compared to individuals who discontinued buprenorphine, those with continuous treatment had significantly lower rates of prescription opioid use and opioid-related events, including medically treated overdoses in the follow-up...
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How proteins help influenza A bind and slice its way to cells
New study adds to our understanding of how influenza A effectively overcomes the first line of our defence against infection ELIFE Researchers have provided new insight on how two proteins help influenza A virus particles fight their way to human cells. The findings, published today in the open-access journal eLife, further explain how influenza A is able to penetrate defensive...
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