OSAKA UNIVERSITY IMAGE: ADMINISTERED RSPO3 AND RSPO3 SECRETED BY ENDOTHELIAL CELLS PROMOTE NEURITE OUTGROWTH AND NEUROPROTECTION BY SUPPRESSING TLR2, TLR4, AND TLR9-INDUCED INFLAMMATION IN MICROGLIA AND BY ACTING DIRECTLY ON NEURONS (A). RSPO3 STIMULATES NUCLEAR TRANSLOCATION OF Β-CATENIN, RESULTING IN THE DOWNREGULATION OF TLR4 EXPRESSION AND PROMOTION OF NEURITE OUTGROWTH (B). CREDIT: STROKE IN PRESS...
