by University of Cambridge Mini-brain organoids showing cortex-like structures. Credit: Andras Lakatos/University of Cambridge Cambridge researchers have developed ‘mini brains’ that allow them to study a fatal and untreatable neurological disorder causing paralysis and dementia—and for the first time have been able to grow these for almost a year. A common form of motor neurone disease,...
UNIVERSITY OF VIRGINIA HEALTH SYSTEM IMAGE: “THIS WORK REPRESENTS THE LARGEST, MOST ANCESTY-DIVERSE STUDY OF TYPE 1 DIABETES THAT IDENTIFIES THE MOST LIKELY CAUSAL GENETIC VARIANTS ASSOCIATED WITH RISK, THEIR TARGET GENES AND THOSE GENES THAT ARE IMPLICATED IN OTHER AUTOIMMUNE DISEASES WITH KNOWN DRUG TARGETS,” SAID RESEARCHER STEPHEN S. RICH, PH.D., OF THE UNIVERSITY...
by Laurie Fickman, University of Houston In this artistic illustration, prepared by Majd’s former student You Jung Kang, IL13 ligands (represented by butterflies) carry the Dp44mT-loaded nanoparticles (represented by honey) from the vein (represented by red pipe) to the tumors (represented by the purple and red bugs), feeding and destroying the tumors. Credit: You Jung Kang...
by Elsevier Primary chondrocytes overexpressing HDAC6 genetically were generated via plasmid transfection. The up-regulation of HDAC6 can deacetylate tubulin in the microtubule system, which interferes with spatial arrangement of mitochondria, leading to degradation of the extracellular matrix (ECM) and up-regulation of reactive oxygen species (ROS). Inhibition of enzyme activity of HDAC6 by Tubastatin A reverses these...
WEIZMANN INSTITUTE OF SCIENCE IMAGE: HUMAN LIVER TISSUE UNDER A MICROSCOPE. COMPARED TO HEALTHY DONORS (LEFT), TISSUE SAMPLES FROM PEOPLE WITH ACUTE LIVER FAILURE (CENTER, RIGHT) REVEAL A SIGNIFICANT INCREASE IN LEVELS OF THE MYC. Acute liver failure is a devastating, rapidly progressing disease that results in death in 80% of cases, unless an emergency...
BOSTON UNIVERSITY SCHOOL OF MEDICINE (Boston)–High blood pressure (hypertension) affects one in two U.S. adults and can cause hardening and thickening of the arteries (atherosclerosis), which can lead to heart attacks, strokes or other complications including chronic kidney disease. Dietary salt intake can evoke salt-sensitive hypertension, which exists in approximately half of hypertensive patients. A...
Parasitic worms could offer a new treatment hope for patients suffering from the autoimmune disease multiple sclerosis, according to experts from the University of Nottingham. The findings of the research, published in the journal JAMA Neurology, show that infecting MS patients with a safe dose of the hookworm parasite Necator americanus induces immunoregulatory responses and...
c zBioIntelliSense, a Silicon Valley company, is unveiling its FDA cleared BioButton device that may help with tracking symptoms of COVID-19 in potential patients and help society return to a normal state of affairs. The BioButton is about the size of a large coin and, with the help of accompanying applications and triage dashboards, it...
Diabetic retinopathy is one of the main vascular complications of type 2 diabetes, and the most common cause of visual deterioration in adults. A new study in The American Journal of Pathology reports on the efficacy of a possible treatment candidate that showed anti-inflammatory and neuroprotective effects on the retina and optic nerve head in...
In fruit flies modeled with IBMPFD disease, mitochondria (red circles) are severely disrupted. Treatment of VCP inhibitors in these diseased flies reversed mitochondrial damage (green circles). UCLA researchers have discovered the molecular basis of, and identified potential treatment for, an incurable disease known as inclusion body myopathy, Paget disease with frontotemporal dementia, or IBMPFD. Using...
