by St. Jude Children’s Research Hospital Wenjian Yang, Shawn Lee, MBBS, and Jun J. Yang, PhD, recently published a comprehensive study pharmacotyping childhood leukemia. Credit: St. Jude Children’s Research Hospital Scientists at St. Jude Children’s Research Hospital are reporting the most comprehensive study to date describing the variations in drug response across different genetic subtypes of acute lymphoblastic leukemia...
by National Institutes of Health PET scan of a human brain with Alzheimer’s disease. Credit: public domain A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer’s disease treatment for those who are at genetic risk, according to findings published in Nature Aging. The research...
by Garvan Institute of Medical Research DNA double helix. Credit: Arek Socha By analyzing genomic data from more than 30,000 people, an international team has revealed thousands of new regulatory regions that control disease-linked genes—a resource that is now available to researchers worldwide. The findings, co-led by the Garvan Institute of Medical Research and published today...
by Jordyn Imhoff, University of Michigan Credit: Pixabay/CC0 Public Domain Diabetes is the leading cause of kidney failure in the United States, but identifying type 1 or type 2 diabetes patients at high risk for progressive kidney disease has never had a sure science behind it. Historically, assessing kidney function meant looking at estimated glomerular filtration...
by RIKEN Figure 1: An interaction map of proteins produced by genes differentially expressed in acute myeloid leukemia cells revealed vulnerabilities that could be targeted using drugs. Credit: Nature Cancer A new combination of drugs that may have the potential to treat a type of leukemia has been uncovered by a detailed molecular examination of leukemia cells...
CHILDREN’S HOSPITAL OF PHILADELPHIA Philadelphia, October 5, 2020–Through genetic sequencing and targeted treatment, researchers from Children’s Hospital of Philadelphia (CHOP) have resolved a severe lymphatic disorder in a young woman with kaposiform lymphangiomatosis (KLA), a complex and rare disorder that causes lymphatic vessels around the heart and lung to leak fluid, causing breathing difficulties, infections, and often...
Since the late 1990s, immunotherapy has been the frontline treatment against lymphomas where synthetic antibodies are used to stop the proliferation of cancerous white blood cells. However, in the more than 20 years since their use began, the molecular mechanisms that underlie this therapy are still little understood. For the first time, scientists from the...
By Rachel Schraer Health reporter A drug that could stop cancer cells repairing themselves has shown early signs of working. More than half of the 40 patients given berzosertib had the growth of their tumours halted. Berzosertib was even more effective when given alongside chemotherapy, the trial run by the Institute of Cancer Research (ICR)...
Two Florida State University researchers are developing a high-tech material currently used in athletic equipment and prosthetics into a special tool to better develop stem cells. The work could improve drug screening, disease modeling, precision medicine, and cell therapy. FAMU-FSU College of Engineering researchers Yan Li, an associate professor in chemical and biomedical engineering, and...
Researchers at Li Ka Shing Faculty of Medicine of The University of Hong Kong (HKU) have successfully demonstrated the use of human induced pluripotent stem cells (hiPSCs) from patients’ skin cells for therapeutic drug testing. The success of the research implies that scientists are one step closer to applying stem cells in precision medicine in treating patients suffering...
