by Perelman School of Medicine at the University of Pennsylvania PBA treatment reduces PERK activity and increases XBP1s in the hippocampus of APPNL-G-F knock-in (KI) mice. Confocal images of the hippocampus across groups. (A) BiP in the CA3. (B) p-PERK in the CA3. (C) ATF4 in the CA1. (D) XBP1s in the CA3. (E) ADAM10 in...
By VANESSA CHALMERS HEALTH REPORTER FOR MAILONLINE PUBLISHED: 13:41 EDT, 10 July 2020 | UPDATED: 13:54 EDT, 10 July 2020 Of a small number of patients, 15% died compared with the 85% expected Overall 70% of patients who were on the brink of death saw improvements The researchers admitted they did not expect such positive...
By Sally Robertson, B.Sc. Researchers in the U.S. have used a new web-based platform to help identify synergistic and antagonistic drug combinations and their underlying mechanisms of action in the context of coronavirus disease 2019 (COVID-19). The tool, called COVID-KOP, prioritized 73 combinations of 32 drugs as potential treatments for severe acute respiratory syndrome coronavirus...
COLUMBIA UNIVERSITY IRVING MEDICAL CENTER EYEDROPS WITH A CASPASE-9 INHIBITOR PREVENT RETINAL INJURY FROM RETINAL VEIN OCCLUSION. IN THE LEFT IMAGE, RVO CAUSES SWELLING IN THE RETINA AND THE RETINAL LAYERS ARE LESS DISTINCT…. view more CREDIT: TROY LAB (CUIMC) NEW YORK, NY (June 29, 2020) — Researchers at Columbia University Irving Medical Center have...
Acute myeloid leukemia (AML) is a hematological malignancy which incidence increases with age, that is biologically, phenotypically, and genetically very heterogeneous. Its treatment uses to combine chemotherapy followed by allogenic Hematopoietic Stem and Progenitor Cells transplant (allo-HSCT), based on the patient’s eligibility, to consolidate complete remission and prevent relapse. Yet, except for a few subgroups,...
There is clear evidence that high sugar consumption leads to obesity and fatty liver disease. Synthetic and natural alternatives to sugar are available, but little is known about the effects of these non-caloric sweeteners on the liver. A new study led by Rohit Kohli, MBBS, MS, shows that stevia extract can reduce markers of fatty...
Exosomes demonstrate ability to enhance anti-tumor effect of platinum-based drugs and to ameliorate peripheral neuropathy HENRY FORD HEALTH SYSTEM NeurExo Sciences, LLC (NXS), a biotechnology company focused on the development of exosome therapies and subsidiary of NeuroTrauma Sciences LLC, and Henry Ford Health System, a non-profit organization, today announced the presentation of new data on exosomes at the International Society for Extracellular Vesicles (ISEV) 2019 Annual Meeting being...
