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Inflammation and pressure-sensing leads to ‘feed-forward’ loop in osteoarthritis

DUKE UNIVERSITY DURHAM, N.C. -An unfortunate biological “feed-forward” loop drives cartilage cells in an arthritic joint to actually contribute to progression of the disease, say researchers at Duke University and Washington University in Saint Louis.  Pain researcher and mechanobiologist Wolfgang Liedtke, a professor of neurology at Duke, partnered with former Duke colleague and cartilage expert Farshid Guilak,...