by The Mount Sinai Hospital Artistic representation of the gene clusters that influence cancer progression in Drs. Xu and Zhang’s latest research study in Genome Research. Credit: Mount Sinai Health System Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a study identifying 4,749 key gene clusters, termed “prognostic modules,” that significantly influence...
by Perelman School of Medicine at the University of Pennsylvania Multivariable Cox Proportional-Hazards Models in the TOPCAT trial. Multivariable Cox proportional-hazards models that include endotrophin, NT-proBNP, and MAGGIC (Meta-Analysis Global Group in Chronic Heart Failure) risk score as predictors of (Panel A) the primary end point, (Panel B) death or heart failure–related hospital admission, and (Panel...
IMAGE: DR ELIZABETH ROUNDHILL, UNIVERSITY OF LEEDS CREDIT: UNVIERSITY OF LEEDS New research has revealed a way to help identify which patients with an aggressive type of bone cancer are least likely to be cured by current standard treatment. For around one in three patients diagnosed with Ewing sarcoma in just one part of the body –...
Heart failure is an endemic disease affecting 250 000 Swedes. Despite new treatments such as modern medicines and defibrillators, the mortality rate is still high and the prognosis worse than for certain cancers. A new study from Lund University in Sweden now shows a link between cognitive impairment and an increased risk for rehospitalisation, or...
by Tabea Kemna, Karolinska Institutet In an interdisciplinary study combining stem cell biology and tumor biology, researchers from Karolinska Institutet (as well as Uppsala and Lund University, together with researchers in Canada, Germany and France), have succeeded in creating a new type of stem cell model for studies on cancer of the brain. The study...
by University of Eastern Finland Biomarkers to support the diagnosis of frontotemporal lobar degeneration (FTLD) and to assess the severity and expected prognosis of the disease are needed. Neurofilament light chain (NfL) measured from a blood sample strongly correlates with the duration of the disease in FTLD patients and the rate of brain atrophy, according...
Analysing the levels of a protein called TonEBP could provide valuable insight into the likelihood of recurrence of hepatocellular carcinoma, an aggressive cancer of the liver, following its surgical removal. Drugs that target TonEBP could also be investigated for liver cancer treatment. Tonicity-responsive enhancer-binding protein (TonEBP) helps protect cells from stress, but also elevates the...
