by CU Anschutz Medical Campus Credit: CC0 Public DomainResearchers at the University of Colorado Anschutz Medical Campus have found that inhibiting a key protein can stop the destruction of synapses and dendritic spines commonly seen in Alzheimer’s disease. The study, whose first author is Tyler Martinez, a student in the Pharmacology and Molecular Medicine Ph.D. program...
Tag: <span>progression</span>
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What to know about type 2 diabetes progression
Type 2 diabetes is a chronic and progressive condition. Over time, people may need to adjust their treatment plan to manage this progression, such as introducing lifestyle changes and taking prescription medication. Type 2 diabetes affects the body’s ability to manage blood sugar levels properly. After diagnosis, lifestyle changes or certain medications might slow or...
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Trial demonstrates one-year progression-free survival in 94% of patients with stage 3 or 4 classic Hodgkin lymphoma
by SWOG Cancer Research Network Credit: Unsplash/CC0 Public Domain A Phase 3 trial has demonstrated that patients with advanced stage (3 or 4) classic Hodgkin lymphoma who underwent initial treatment with nivolumab, a PD-1 checkpoint inhibitor, and AVD chemotherapy (N-AVD) had a significantly lower risk of their cancer getting worse than patients treated with brentuximab...
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Biomarkers for the progression of type 2 diabetes identified
by University of Montreal NogoR enhances glucose clearance and insulin sensitivity in HFD mice. Two separate cohorts of wild-type male C57BL/6 J mice were maintained on a high-fat diet for 6 weeks, then injected for 14 consecutive days with saline or 100 ng (2.1 pmol/animal) recombinant NogoR. a, b Body weights of cohort one and circulating glucose levels during an oral glucose...
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Protein partnership effectively fends off pancreatic cancer progression
by Virginia Commonwealth University Model for the functional interaction between Smad4 and Prdm16 during PDAC formation and progression. Credit: Journal of Cell Biology (2023). DOI: 10.1083/jcb.202203036 Scientists at VCU Massey Cancer Center have uncovered a previously unrecognized relationship between two sets of proteins that operate in tandem to fend off the growth of pancreatic cancer. The findings...
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Discovery suppresses progression of kidney fibrosis
by Virginia Tech Webster Santos, the Cliff and Agnes Lilly Faculty Fellow in the Virginia Tech College of Science and a professor in the Department of Chemistry, in his lab at Davidson Hall. Credit: Greg Atkins, Virginia Tech Webster Santos is determined to find a way to halt kidney fibrosis, a condition caused by persistent...
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Study finds daily steroids safe and slow the progression of Duchenne muscular dystrophy
by Mark Michaud, University of Rochester Medical Center Skeletal muscle fibers. Credit: Berkshire Community College Bioscience Image Library / Public domain New research published in JAMA recommends daily steroid doses for children with Duchenne muscular dystrophy (DMD), marking a significant change in how the disease is treated. University of Rochester Medical Center (URMC) neurologist Robert Griggs, M.D.,...
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Predicting the progression of rheumatoid arthritis
by Tokyo Medical and Dental University PRS of patients with severe radiographic progression was significantly higher than that of patients with non-severe progression. Credit: Department of Genomic Function and Diversity, TMDUPredicting the future may be beyond our grasp, but what about predicting disease progression? Researchers in Japan have delved into the human genome to investigate...
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Newly discovered proteins protect against progression of diabetic kidney disease
JOSLIN DIABETES CENTER IMAGE: THE CUMULATIVE INCIDENCE OF END-STAGE RENAL DISEASE (ESRD) ACCORDING TO INDEX OF PROTECTION OF THREE PROTEINS, INDEX=0/3 INDICATES NO PROTECTION WHEREAS INDEX=3/3 INDICATES FULL PROTECTION. CREDIT: COPYRIGHT JOSLIN DIABETES CENTER Elevated levels of three specific circulating proteins are associated with protection against kidney failure in diabetes, according to research from the...
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Stopping the onset and progression of intractable immune diseases
POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY (POSTECH) IMAGE: SCHEMATIC DIAGRAM DEPICTING ANTI-INFLAMMATORY RESPONSE MECHANISMS MEDIATED BY MGCP. CREDIT: POSTECH The development of therapeutic drugs for inflammatory bowel disease, an intractable immune disease, and multiple sclerosis – an autoimmune disorder – is gaining traction. A research team from the Department of Life Sciences at POSTECH and a joint research team...
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