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The promising drug duo that may improve spinal muscular atrophy treatment
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The promising drug duo that may improve spinal muscular atrophy treatment

by  Cold Spring Harbor Laboratory Graphical abstract. Credit: Cell (2022). DOI: 10.1016/j.cell.2022.04.031 In 2016, Spinraza became a game-changer for spinal muscular atrophy (SMA) patients. It was the first FDA-approved treatment for the neurodegenerative disease, which is the leading genetic cause of infant death. The drug was conceived and developed by Cold Spring Harbor Laboratory (CSHL) Professor Adrian Krainer and collaborators. But Krainer...

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Promising drug for treating serious COVID-19 complication in children

Scientists at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital (BWH) have identified a promising drug candidate for the treatment of multi-inflammatory syndrome in children (MIS-C), they report in Clinical Care Explorations. MIS-C is a rare but severe and potentially life-threatening condition that usually develops in children weeks to months after they have experienced a mild...

Researchers identify promising drug to treat gastrointestinal cancers
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Researchers identify promising drug to treat gastrointestinal cancers

by Joe Dangor, Mayo Clinic Credit: Unsplash/CC0 Public Domain Gastrointestinal cancers are some of the most commonly diagnosed cancers, and they continue to be associated with poor survival outcomes. The drug adagrasib specifically targets the KRASG12C gene mutation that is common in gastrointestinal cancers and inhibits gastrointestinal function. Tanios Bekaii-Saab, M.D., an investigator from Mayo...

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Mice study identifies action mechanism of a promising drug against Alzheimer’s disease

Reviewed by Emily Henderson, B.Sc.,Dec 9 2020 A study conducted on mice published in the journal Geroscience has identified the action mechanism of a promising compound against Alzheimer’s disease, developed by the team of Medical Chemistry and Pharmacology at the University of Barcelona. The new drug belongs to a family of molecules that, when bound to imidazole...