by Institute of Cancer Research Mechanism of action of 2-OHOA. (1) 2-OHOA regulates the cell membrane composition by both direct incorporation into the lipid bilayer and regulation of important lipid metabolism enzymes. (2) Among other structural effects on the lipid bilayer, these changes in lipid composition regulate the raft-to-nonraft lipid balance, which causes translocation of numerous...
Peer-Reviewed Publication WILEY In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab—an antibody that targets a protein expressed on certain immune cells—was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus. In...
by King’s College London Overall Survival for Patients With Recurrent Glioblastoma Kaplan-Meier plot comparing overall survival for patients with recurrent glioblastoma treated with autologous tumor lysate-loaded dendritic cell vaccination (DCVax-L; ie, patients who were randomized to the placebo group and who crossed over to begin DCVax-L following recurrence) and 640 contemporaneous, matched external controls derived...
