by Roswell Park Comprehensive Cancer Center Mitochondria are dysfunctional in neuroendocrine prostate tumors. Credit: Oncogene (2024). DOI: 10.1038/s41388-024-03261-4 A team of researchers at Roswell Park Comprehensive Cancer Center, led by Dhyan Chandra, Ph.D., has discovered a new therapeutic target for neuroendocrine prostate cancer, a rare and hard-to-treat form of prostate cancer. Their findings, published in the journal Oncogene, suggest...
Tag: <span>Prostate cancer</span>
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MRI-first strategy for prostate cancer detection proves deemed safe and effective
by Charité – Universitätsmedizin Berlin An MRI scanner like this one can be used to take images showing whether a patient has aggressive prostate cancer. Credit: Charité | Rafael Poschmann There are several strategies for the early detection of prostate cancer. The first step is often a blood test for prostate-specific antigen (PSA). If PSA levels...
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African men most at risk of prostate cancer—new study flags genetic causes
by Wenlong Carl Chen, The Conversation Credit: Unsplash/CC0 Public Domain A breakthrough study has identified the genetic risk factors that contribute to increased prostate cancer in African men. The study, the largest of its kind, recruited 7,500 men from eastern, southern and west Africa. The study is especially important because African men have a high risk...
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Researchers discover why taking a mushroom supplement slows or prevents prostate cancer from getting worse
by City of Hope National Medical Center Effects of WBM extract on tumor growth in TRAMP-C2 flank tumor xenograft models. Credit: Clinical and Translational Medicine (2024). DOI: 10.1002/ctm2.70048 Researchers at City of Hope now understand why taking an investigational white button mushroom supplement shows promise in slowing and even preventing prostate cancer from spreading among men who joined...
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Synthetic vitamin K precursor found to slow progression of prostate cancer in lab mice
by Bob Yirka , Medical Xpress Dietary pro-oxidant therapy using a vitamin K precursor. Credit: Science (2024). DOI: 10.1126/science.adk9167 A team of molecular biologists and other medical specialists at Cold Spring Harbor Laboratory in New York, working with a large number of international partners, reports evidence that a synthetic vitamin K precursor can be used to slow...
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New insights show ASCL1’s role in neuroendocrine prostate cancer, an aggressive and treatment-resistant type
by Jim Stallard, Memorial Sloan Kettering Cancer Center Molecular characterization of PtPM and RPM primary prostate tumor transplants demonstrates emergence of neuroendocrine carcinoma marker expression. Credit: Nature Cancer (2024). DOI: 10.1038/s43018-024-00838-6 A scientist whose discoveries about prostate cancer have led to lifesaving treatments is now shedding light on an emerging and deadlier form of the disease: neuroendocrine prostate...
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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?
by Sathana Dushyanthen and David Kok, The Conversation Comparison of differences between traditional radiotherapy and stereotactic radiotherapy. Credit: Precision Radiation Oncology Prostate cancer is Australia’s most commonly diagnosed cancer. One in six men will be diagnosed by the time they turn 85. Cancers are abnormal groups of cells that grow uncontrollably and start invading neighboring sites. They can also spread to...
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Vitamin K supplement slows prostate cancer in mice, researchers discover
by Cold Spring Harbor Laboratory A new study from Cold Spring Harbor Laboratory Professor Lloyd Trotman and colleagues, published in Science, shows that menadione significantly slows prostate cancer growth in mice and in human-derived cancer cells, as seen here. Credit: Trotman lab/Cold Spring Harbor Laboratory Prostate cancer is a quiet killer. In most men, it’s treatable. However,...
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Researchers evaluate beneficial effects of fermented black garlic extract on prostate cancer
Effects of aged black garlic water extract (ABGE) on cell proliferation of control prostate (PNT-2) (a), androgen-dependent (LNCaP) (b), and androgen-independent (PC-3) (c) prostate cancer (PCa) cells. Cell proliferation and growth were evaluated by resazurin reagent after incubation for 24, 48, and 72 h of PNT-2, LNCaP, and PC-3 cell lines with ABGE at different...
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Protein NSD2 found to drive early prostate cancer development
September 9, 2024 by University of Michigan Prostate cancer cells. Credit: NIH Image GalleryResearchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason that a typically normal protein goes awry and fuels cancer. They found that the protein NSD2 alters the function of the androgen receptor, an important regulator of...