By PROF. KARIM FIZAZI, MEDICAL ONCOLOGIST, INSTITUTE GUSTAVE ROUSSY AND PROFESSOR IN ONCOLOGY, UNIVERSITY OF PARIS-SACLAY, VILLEJUIF, FRANCE CREDIT: ESMO Lugano, Switzerland, 19 September 2021 – A novel combination of well-known drugs prolongs survival in patients with hormone/castration-sensitive prostate cancer, according to late breaking research presented at the ESMO Congress 2021. (1,2) The PEACE-1 and STAMPEDE studies found that the addition of abiraterone acetate plus prednisolone (AAP) to standard therapy lengthened survival compared...
Tag: <span>Prostate cancer</span>
Post
Orchid extract holds hope for prostate cancer treatment
by Centenary Institute Figure 1. Erianin suppresses colony formation but not migration in both LNCaP and PC3 cells. (A, B) Cells were treated with erianin at indicated concentrations for 10 days. Images are representative of three independent experiments (A) and the number of colonies was quantified (B). (C, D) Wound healing assay was performed to assess cell...
Post
Best ways to treat to reoccurring prostate cancer
by Michael Addelman, University of Manchester Figure 1 PRISMA flow chart of literature search. Credit: DOI: 10.3389/fonc.2021.681448 Despite advances in radiation treatment for prostate cancer, an established technique, it can reoccur in some patients most often within the prostate gland itself. Localized recurrence is treatable and in many cases curative, however there is no consensus on the...
Post
Understanding and targeting prostate cancer metabolism
by Flinders University (A) Two distinct AR siRNAs (siAR (1) and siAR (2); 12.5 nM) reduce the expression of 6PGD at the protein level in LNCaP cells. Cells were transfected with 12.5 nM of each siRNA; after 48 h, proteins were extracted and assessed by Western blotting. (B) siAR (2) reduces the expression of 6PGD mRNA...
Post
Genomic test could help predict aggressive disease in men newly diagnosed with prostate cancer
An analysis of patient data from across Michigan found scores from the Decipher Biopsy test independently aligned with outcomes. After a biopsy comes back positive for prostate cancer, patients and their doctors are often left with a choice between taking a watch-and-wait approach, known as active surveillance, or proceeding with surgery or radiation. And identifying...
Post
Anti-androgen therapy can fuel spread of bone tumours in advanced prostate cancer
QUEENSLAND UNIVERSITY OF TECHNOLOGY Dr. Bock, under the mentorship of Distinguished Professor Dietmar Hutmacher, from QUT Centre for Biomedical Technologies, has focused her research on bone metastases from breast and prostate cancers. She developed 3D miniature bone-like tissue models in which 3D printed biomimetic scaffolds are seeded with patient-derived bone cells and tumor cells to...
Post
Immunotherapy may be effective for subset of prostate cancer
BETH ISRAEL DEACONESS MEDICAL CENTER Boston – In recent years, cancer immunotherapy has been effective in treating patients with immunogenic, or so-called “hot” tumors with increased levels of inflammation and the presence of immune cells in and around the tumors. Prostate cancer, however, is considered a “cold” tumor, with few immune cells recognizing and infiltrating...
Post
Oncotarget: Prostate cancer and a possible link with schizophrenia
IMPACT JOURNALS LLC Oncotarget published “The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia” reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable...
Post
Precision prevention for prostate cancer
by University of Delaware Aditya Dutta and research collaborators found that, under conditions of stress, the NKX3.1 gene, which is critical in prostate biology, moves to the mitochondria — the powerhouse of the cell — in order to protect against prostate cancer. Credit: University of Delaware The University of Delaware’s Aditya Dutta and collaborators are investigating the NKX3.1...
Post
When should screening start for men with a family history of prostate cancer?
by Public Library of Science Credit: CC0 Public Domain A nationwide study in Sweden estimates the elevated risk of advanced or fatal prostate cancer among relatives of men with the disease, providing new data that could help refine guidelines for the age at which screening should begin. Mahdi Fallah and Elham Kharazmi of the German Cancer...