by University of East Anglia Presence and composition of urine microbiota identify participants with a poorer prognosis. The figure presents an analysis of 16S OTU sequence from urine sediments. (A) Principal coordinate analysis (Manhattan distance) of family-level OTU data from urine sediments from 46 patients undergoing assessment for prostate cancer. Clustering with k-means suggested three...
by Carla K. Johnson This 1974 microscope image made available by the Centers for Disease Control and Prevention shows changes in cells indicative of adenocarcinoma of the prostate. Some doctors say it’s time to rename low-grade prostate cancer to eliminate the alarming C word. About 34,000 Americans die from prostate cancer annually, but most prostate...
The U.S. Food and Drug Administration approved Pluvicto (lutetium Lu 177 vipivotide tetraxetan) for treatment of adults with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who have received androgen receptor pathway inhibition and taxane-based chemotherapy. Simultaneously, the agency also approved the first radioactive diagnostic agent for patient selection in the use of a...
by Mary Ann Liebert, Inc Prostate cancer cells. Credit: NIH Image Gallery A novel high-throughput screening assay is designed to identify inhibitors of the androgen receptor, which plays a critical role in the progression of prostate cancer. The assay could be used to identify new drugs to treat resistant forms of prostate cancer, as described...
by Johannes Angerer, Medical University of Vienna KMT2C methyltransferase deficiency triggers metastatic dissemination of prostate cancer. a H&E stains of urinary tract obstruction by invasive PCa in a moribund Pten∆/∆Kmt2cSET∆/∆ mouse at 39 weeks p.p. at low (top) and high (bottom) magnification. Scale bars: 200 µm. T, tumor; U, urethra. b H&E-stained sections and IHC analysis of the...
by Imperial College London Micrograph showing prostatic acinar adenocarcinoma (the most common form of prostate cancer) Credit: Wikipedia An ultrasound scan can be used to detect cases of prostate cancer, according to new research. Researchers at Imperial College London, University College London and Imperial College Healthcare NHS Trust have found that a new type of...
MASSACHUSETTS GENERAL HOSPITAL BOSTON – Results from an international, randomized, double-blind, placebo-controlled, phase 3 clinical trial indicate that adding the androgen-receptor inhibitor darolutamide to androgen-deprivation therapy and chemotherapy prolongs the survival of men with metastatic, hormone-sensitive prostate cancer, a disease that is fatal in most cases. The study, which was conducted by a team led by investigators at...
Dogs are proving to be a far better scientific model for study of prostate cancer than mice, the typical animal used in the lab for this type of research. In the first use of canines in an advanced prostate cancer study, scientists explored the pathways used by the cancer to evade the immune system and...
The combination of a novel blood test and magnetic resonance imaging (MRI) can reduce overdiagnosis of low-risk cancers as well as societal costs in prostate cancer screening, according to a cost-effectiveness study from Karolinska Institutet published in the journal European Urology. The results provide support for organised prostate cancer testing in Sweden, researchers say. A barrier to...
JANUARY 21, 2022 by Society of Nuclear Medicine and Molecular Imaging PET disease extent in EAU BCR low-risk patients, EAU BCR high-risk patients, and BCP patients (A) and predictors of PET M1 disease (B). OR = odds ratio. Credit: Justin Ferdinandus, Wolfgang P. Fendler, Andrea Farolfi, et al. New research has confirmed the accuracy of...
