Molecular characterization of ebselen binding activity to SARS-CoV-2 main protease AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE The synthetic drug ebselen can bind to both the catalytic region and a previously unknown distant site on the SARS-CoV-2 virus’ main protease, according to a molecular simulation analysis of the drug’s interactions with this enzyme. The results...
Tag: <span>protease</span>
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COVID-19 research: Anti-viral strategy with double effect
Frankfurt scientists identify possible Achilles’ heel of SARS-CoV-2 virus GOETHE UNIVERSITY FRANKFURT In the case of an infection, the SARS-CoV-2 virus must overcome various defense mechanisms of the human body, including its non-specific or innate immune defense. During this process, infected body cells release messenger substances known as type 1 interferons. These attract natural killer...
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Inhibiting a protease could improve the treatment of inflammatory bowel disease
The study, published in EMBO Molecular Medicine, shows that blockade of the protease MT1-MMP protects the vasculature in the inflamed gut CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Centro de Investigaciones Biológicas (CIB) of the Consejo Superior de Investigaciones Científicas (CSIC) have identified...