Frankfurt scientists identify possible Achilles’ heel of SARS-CoV-2 virus GOETHE UNIVERSITY FRANKFURT In the case of an infection, the SARS-CoV-2 virus must overcome various defense mechanisms of the human body, including its non-specific or innate immune defense. During this process, infected body cells release messenger substances known as type 1 interferons. These attract natural killer...
Tag: <span>proteasome inhibition</span>
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Erectile dysfunction drugs can help cells destroy misfolded proteins
by Harvard Medical School The aberrant buildup of misfolded proteins is a hallmark of a host of disorders, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Aggregates of these toxic proteins wreak havoc on the function of cells, tissues, and organs, and despite intensive research over many decades, there are still no effective means to...
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The death marker protein cleans up your muscles after exercise
by University of Copenhagen Researchers at the University of Copenhagen’s Department of Nutrition, Exercise and Sports have demonstrated that physical activity prompts a clean-up of muscles as the protein ubiquitin tags onto worn-out proteins, causing them to be degraded. This prevents the accumulation of damaged proteins and helps keep muscles healthy. Physical activity benefits health...
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New cancer immunotherapy targeting myeloid cells slows tumor growth
Inhibiting a molecule hijacked by tumor cells to suppress the immune system shrank tumors PHILADELPHIA – Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions. Reporting in Nature Cancer, the...
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New test strip could provide accurate point-of-care diagnostics for cancer, COVID-19
by James Ives, M.Psych. (Editor) A new synthetic paper for finger-prick blood tests could provide accurate point-of-care diagnostics for cancer, COVID-19, and other serious diseases. Researchers at KTH Royal Institute of Technology say the innovation allows the detection of important biomarker proteins that might otherwise evade the blood plasma screening process. There are proteins in...
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Good news for menopausal women taking hop supplements: Tests show no drug interactions
CORVALLIS, Ore. – Hop-based dietary supplements that many women use to ease the night sweats and hot flashes commonly reported during menopause aren’t likely to cause drug interactions, new research from Oregon State University’s Linus Pauling Institute and College of Pharmacy shows. The findings are important because while hormone replacement therapy remains the standard of...
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The evolution of proteasome inhibition: A personal journey from early research to approval
My 16 plus years at Takeda Oncology have given me the opportunity to participate in and contribute to the evolution of treatment for multiple myeloma, a rare cancer that affects nearly 230,000 people around the world, according to five-year prevalence estimates.1 While the disease remains incurable, we have made important advances in research and development in recent years....