by Weizmann Institute of Science Twelve days after injury, the lining of the colon was much more inflamed in mice lacking the NLRP10 inflammasome in their intestinal epithelial cells (bottom) than in the controls (top). Credit: Weizmann Institute of Science A new study by Prof. Eran Elinav’s lab at the Weizmann Institute of Science got an...
by Alex Viveros, Broad Institute of MIT and Harvard The SHOC2-MRAS-PP1C complex is made up of three proteins that regulate the RAS signaling pathway and help cancer cells with RAS mutations survive. Credit: Broad Institute and Dana-Farber Cancer Institute Some of the most infamous drivers of cancer are mutations in RAS genes, which lead to tumor...
UNIVERSITY OF SOUTH FLORIDA (USF HEALTH) IMAGE: ZHIGAO WANG, PHD, ASSOCIATE PROFESSOR OF CARDIOVASCULAR SCIENCES, IN HIS LABORATORY AT THE USF HEALTH HEART INSTITUTE, UNIVERSITY OF SOUTH FLORIDA. IMAGES ON THE MONITOR DEPICT TWO TYPES OF CELL DEATH: APOPTOSIS (LEFT) AND NECROPTOSIS. CREDIT: USF HEALTH/UNIVERSITY OF SOUTH FLORIDA TAMPA, Fla. (Feb. 18, 2022) – Cell death...
GEISINGER HEALTH SYSTEM A discovery by a team of researchers, led by a Geisinger professor, could yield a potential new treatment for breast cancer. In a study published this month in Cell Reports, the team used small molecules known as peptides to disrupt a complex of two proteins, RBM39 and MLL1, that is found in breast cancer...
A team of ETH researchers led by Karsten Weis has developed a method that allows them to study the assembly process for large protein complexes in detail for the first time. As their case study, the biologists chose one of the largest cellular complexes: the nuclear pore complex in yeast cells. Cells produce a great...
July 6, 2018, St. Jude Children’s Research Hospital Like a mentor helping medical students choose between specialties, a protein complex helps shape the destiny of developing T cells, St. Jude Children’s Research Hospital scientists have reported. The research appears today in the journal Science Immunology and adds to growing evidence of the critical role cell metabolism plays in the immune system. Corresponding author Hongbo...
