by University of Birmingham PF4 binding to c-Mpl disrupts TPO binding. (A) AlphaFold prediction of the binding of PF4 and TPO to c-Mpl. Overlayed cartoon structures of c-Mpl (green) complexed with either PF4 (blue) or TPO (orange) as modeled using Colabfold. Structure predictions were ranked by pLDDT, a per-residue measure of the confidence of the predicted...
by Tokyo Medical and Dental University PQBP1 functions in brain microglia, which corresponds to dendritic cells or a part of macrophage regulating innate immune system, as an intracellular receptor for HIV cDNA and Tau proteins similarly. Credit: Department of Neuropathology, TMDU Just as a home security system can alert a homeowner to the presence of...
by Bill Snyder, Vanderbilt University Forty years since its discovery, much remains to be discovered about an enzyme called CaMKII that plays a key role in shaping learning and memory in the brain. Now Roger Colbran, Ph.D., graduate student Tyler Perfitt and colleagues report in the Journal of Neuroscience the discovery of a novel interaction...
