by Spanish National Research Council Credit: Pixabay/CC0 Public Domain A team with the participation of researchers from the Institute for Advanced Chemistry of Catalonia (IQAC) of the Spanish National Research Council (CSIC) has revealed the structure of the protein responsible for Huntington’s disease, a severe neurodegenerative pathology characterized by the progressive disorder of movement and cognitive function. This research, published in the journal Nature...
SCRIPPS RESEARCH INSTITUTE IMAGE: HIGH-RESOLUTION IMAGES SHOWING THE FULL LENGTH OF E1E2 IN COMPLEX WITH THREE BROADLY NEUTRALIZING ANTIBODIES, FROM TWO ANGLES. CREDIT: SCRIPPS RESEARCH LA JOLLA, CA—A team led by scientists at Scripps Research and the University of Amsterdam has achieved an important goal in virology: mapping, at high resolution, critical proteins that stud...
UNIVERSITY OF SOUTHERN CALIFORNIA IMAGE: ARTIST’S RENDERING OF GABA TRANSPORTER 1 (GAT-1) EMBEDDED IN A NEURON’S MEMBRANE. TIAGABINE (GREEN) BLOCKS GAT-1 FROM SHUTTLING THE NEUROTRANSMITTER GABA (YELLOW AND RED) INTO THE CELL FROM THE SYNAPSE. (ILLUSTRATION: YEKATERINA KADYSHEVSKAYA.) CREDIT: USC DORNSIFE/YEKATERINA KADYSHEVSKAYA In brief: Scientists have, for the first time, determined the structure of a...
MASSACHUSETTS INSTITUTE OF TECHNOLOGY IMAGE: MIT CHEMISTS HAVE DISCOVERED HOW THE STRUCTURE OF THE EMRE TRANSPORTER CHANGES AS A COMPOUND MOVES THROUGH IT. AT LEFT IS THE TRANSPORTER STRUCTURE AT HIGH PH. AS THE PH DROPS (RIGHT), THE HELICES BEGIN TO TILT SO THAT THE CHANNEL IS MORE OPEN TOWARD THE OUTSIDE OF THE CELL,...
Berkeley Lab researchers helped validate new AI-based algorithm, RosETTAFold, to generate hundreds of new protein structures. 3D view of human interleukin-12 bound to its receptor. Photo credit: Ian Haydon / Berkeley Lab “The dream of predicting a protein shape just from its gene sequence is now a reality,” said Paul Adams, Associate Laboratory Director for Biosciences at...
by Leila Gray Ian HaydonResearchers used artificial intelligence to generate hundreds of new protein structures, including this 3D view of human interleukin-12 bound to its receptor. Scientists have waited months for access to high-accuracy protein structure prediction since DeepMind presented remarkable progress in this area at the 2020 Critical Assessment of Structure Prediction, or CASP14, conference. The...
