by Olivia Dimmer, Northwestern University Credit: Pixabay/CC0 Public Domain The fast motor kinetics of prestin, a protein found in the inner ear, is essential for hearing high-frequency sounds, according to a Northwestern Medicine study published in the Proceedings of the National Academy of Sciences. All mammals, including humans, rely on outer hair cells in the ear’s cochlea to amplify...
Scientists are looking into the causes of gout. Design by MNT; Photography by Hulton Archive/Getty Images & Solskin/Getty Images An international research team identified a novel molecular pathway believed to cause gout and its progression to erosion of joint tissue. Researchers believe lubricin, a protein found in joint fluid, may serve as a novel therapeutic...
by University of California – San Diego Pancreatic cancer cells (nuclei in blue) are shown growing as a sphere encased in membranes (red). Credit: National Cancer Institute Pancreatic cancer is the third deadliest cancer in the United States, after lung and colorectal, though far less common. It is also among the hardest to effectively treat,...
9 January 2023 Representative images of a WM983B melanoma cell nucleus with a nuclear envelope bleb stained for Lamin A/C (green), Lamin B1 (magenta) and DNA (blue). Scale bar, 10 μm The study, published today in Nature Cell Biology, modelled the behaviour of aggressive melanoma cells that are able to change the shape of their nucleus to...
by Ecole Polytechnique Federale de Lausanne Tumor with FMRP-deficient cancer cells (in green) being infiltrated and attached by killer (CD8) T cells. Credit: Jeremy Guillot (Hanahan Lab – EPFL). Immunotherapy is a cutting-edge approach to treating cancer by turning the patient’s own immune system against their tumor. Our increasing knowledge of the mechanisms by which...
by University of North Carolina at Chapel Hill School of Medicine Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111580 Scientists at the UNC School of Medicine and UNC Eshelman School of Pharmacy, in collaboration with a team from Queen Mary University of London, have illuminated the molecular events underlying an inherited movement and neurodegenerative disorder known as ARSACS—Autosomal...
by Delthia Ricks, Medical Xpress Identification of specific anatomical tracts using tau-PET seeds from each clinical group. Credit: J. Therriault, et al., Science Translational Medicine (2022) New imaging of patients with Alzheimer’s demonstrates how a telltale protein spreads throughout the brain based on the phenotype of the disease, i.e., whether the condition is dominated by forgetfulness, or...
by University of Montreal Numb is essential for long-term survival of RGCs. (A to L) Single-plane confocal images of retinal flat mounts stained for Brn3b from 5- (A to D), 8- (E to H), and 20-month-old (I to L) WT, Nbl KO, Numb+/−; Nbl KO, and cDKO mice, as indicated. Images were taken in the...
by Jonathan Deutschman, Johns Hopkins University Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.111478 Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis happen when the immune system is inadvertently activated, mistakenly attacking the body’s tissues and organs. Though it is known that genetics play a role in the development of these disorders, prevention and treatment approaches...
by Olga Kuchment, Texas A&M University Credit: Pixabay/CC0 Public Domain Many diseases have at their origin a protein that does not function properly. Now, a multidisciplinary research team with Texas A&M AgriLife and Texas A&M University has found a way to deliver a protein quickly, effectively and briefly to the brain, with therapeutic and scientific implications....
