UNIVERSITY OF ARIZONA IMAGE: YEAST WITH A RED FLUORESCENT PROTEIN MARKING THE VACUOLE – THE NUTRIENT STORAGE COMPARTMENT OF THE CELL – AND A GREEN FLUORESCENT PROTEIN MARKING AGGREGATES OF TORC1 THAT FORM IN CELLS MISSING AIT1. CREDIT: ANDREW CAPALDI AND TEAM Like bacteria, yeasts are found everywhere, even in and around our bodies. And,...
by Catarina Pietschmann, Max Delbrück Center for Molecular Medicine Three-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Center for Cancer Research, National Cancer Institute, National Institutes of Health Every cell has two mechanisms for repairing DNA single- or double-strand breaks, which...
by University of Southern California Credit: Pixabay/CC0 Public Domain A mutation in a newly discovered small protein is connected to a significant increase in the risk for Alzheimer’s disease, expanding the known gene targets for the disease and presenting a new potential avenue for treatment, according to a new USC study. The protein, called SHMOOSE,...
by King’s College London Illustration of the cardiac FunSel screening system. The system generates a pool of AAV9 vectors to inject into mice and transduce heart cells, which are sequenced to identify protective factors. Credit: G. Ruozi, et al., Science Translational Medicine (2022) Scientists working to develop new therapies and treatments for heart failure patients have discovered...
by Pohang University of Science & Technology (POSTECH) Changes in the amount of amyloid-β aggregates in brain tissue following the administration of DTMB drug. Credit: POSTECH Alzheimer’s disease is a representative neurodegenerative disease showing up at an increasing rate in an aging society. Sufferers of this disease are not only portrayed in media, but can...
by Julia Moióli, FAPESP Researchers at the University of São Paulo showed, through experiments on animals and genetically modified cells, that this type of cancer advances more slowly when the light-sensitive molecule known as melanopsin is deactivated. The discovery could point to novel therapeutic strategies. Credit: Wikimedia Commons Melanopsin (OPN4) is a light-sensing protein found in...
The finding could eventually lead to possible therapies for the especially dangerous melanoma and pancreatic adenocarcinoma, as well as the most common type of childhood brain cancer and adult skin cancer. The study appears in the journal Life Science Alliance. The discovery concerns the GLI1 protein, which is important in cell development but has also been found...
By Nicole Wetsman Jul 28, 2022, 7:00am EDT A protein structure identified by AlphaFold. Image: DeepMind DeepMind is releasing a free expanded database with its predictions of the structure of nearly every protein known to science, the company, a subsidiary of Google parent Alphabet, announced today. DeepMind transformed science in 2020 with its AlphaFold AI software, which produces highly accurate...
by Daegan Miller, University of Massachusetts Amherst Lila Gierasch (center), professor of biochemistry and molecular biology at UMass Amherst. Credit: UMass Amherst In a major new development in the quest to develop better gene therapies with which to treat a host of diseases, researchers at the University of Massachusetts Amherst and UMass Chan Medical School recently...
by American Heart Association Credit: Pixabay/CC0 Public Domain Heart damage is common among patients hospitalized with COVID-19, leading many to wonder how the virus affects the heart. Now, researchers have found that the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to heart muscle injury through the inflammatory process, according...
