The main aim of biopharmaceutical formulation is to ensure safe and stable drugs. Protein stabilization can sometimes be difficult to attain, and in such instances, advanced solutions are required. Human serum albumin has properties which allow it to stabilize proteins in solution, preventing aggregation, oxidation and adsorption. The capacity to stabilize has its basis in...
Tag: <span>proteins</span>
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Proteins that protect against joint inflammation identified
Endogenous proteins that play a vital part in allergies and parasitic infection can prevent the immune system from wrongly attacking the body and causing inflamed joints, a study from Karolinska Institutet published in the scientific journal PNAS reports. The researchers hope that the results will give rise to new drugs for rheumatoid arthritis. In protecting...
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U. Iowa team is developing new delivery tools for gene editing
Engineered peptides provide efficient, non-toxic delivery of gene-editing proteins to airway cells UNIVERSITY OF IOWA HEALTH CARE News of advances in gene-editing technology raises the prospect of actually using this approach to treat disease in patients. But one of the hurdles that remains is how to deliver these tools to the right cells in the patients safely and efficiently. Scientists led by University of Iowa researcher Paul...
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Study unveils the intricate way two proteins interact to promote cell movement, metastasis
Posted Today When cells in our bodies need to move—to attack infection or heal a wound, for example—cellular proteins send and receive a cascade of signals that directs the cells to the right place at the right time. It’s a process cancer cells can hijack to spread to new tissues and organs. Now, a team...
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Scientists discover the structure of cancer molecule
By Maria Cohut Fact checked by Jasmin Collier Alternative splicing is a complex but insufficiently understood process. It is crucial to the production of proteins necessary to cell health. Researchers now believe that cancer cells also use this process to their own advantage. Proteins are large molecules that are absolutely crucial to the health of every single...
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Scientists isolate protective proteins that influence outcomes for type 2 diabetes
by Trinity College Dublin Scientists from the School of Medicine, Trinity College Dublin, have, for the first time, discovered a family of proteins that are associated with lower blood sugar levels among obese patients with type 2 diabetes. Their research is published today in the international journal Nature Communications. The study showed that patients with type 2 diabetes who have high levels...
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Helping transplanted stem cells stick around and do their jobs
New microgel encapsulation method paves the way for more efficient cell therapies WYSS INSTITUTE FOR BIOLOGICALLY INSPIRED ENGINEERING AT HARVARD Bone marrow transplants of hematopoietic stem cells have become standard treatment for a host of conditions including cancers of the blood and lymphatic systems, sickle cell anemia, inherited metabolic disorders, and radiation damage. Unfortunately, many bone marrow transplants...
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Patterns in DNA reveal hundreds of unknown protein pairings
Posted Today Sequencing a genome is getting cheaper, but making sense of the resulting data remains hard. Researchers have now found a new way to extract useful information out of sequenced DNA. By cataloging subtle evolutionary signatures shared between pairs of genes in bacteria, the team was able to discover hundreds of previously unknown protein interactions. This method...
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Fast new directed evolution technique makes viruses create drug proteins in days
Michael Irving Evolution is one of nature’s most impressive forces, allowing organisms to adapt to changing environments to survive. By harnessing and guiding that process scientists have managed to manipulate micro-organisms into producing useful new drugs and materials, but it’s still a time-consuming process. Now, researchers at the University of North Carolina (UNC) have developed a new tool that speeds...
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Musician, 21, drops dead from a caffeine overdose after drinking a protein shake – as his devastated family issue a desperate warning that one TEASPOON can kill
Lachlan Foote was one day shy of his 22nd birthday when he was found dead A coroner’s report has concluded he died of ingesting lethal amount of caffeine Mr Foote’s family want caffeine powder banned in Australia after his death A healthy young musician suddenly died from a caffeine overdose after drinking a protein shake. Lachlan Foote was one day shy of his 22nd birthday when his parents found him dead on the bathroom floor of his family’s...