The nucleus of a cell is well-shielded by a double membrane to protect its most sensitive possession—its DNA. Anything that enters or exits must pass through the nuclear pores, cylindrical structures made of hundreds of proteins. Scientists have made great advances in figuring out the architecture of the pore by reconstructing each of its parts in the...
Tag: <span>proteins</span>
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New research shows SARS-CoV-2 spike proteins disrupt the blood-brain barrier
TEMPLE UNIVERSITY HEALTH SYSTEM IMAGE: SERVIO H. RAMIREZ, PHD, PROFESSOR OF PATHOLOGY AND LABORATORY MEDICINE AT THE LEWIS KATZ SCHOOL OF MEDICINE AT TEMPLE UNIVERSITY AND PRINCIPAL INVESTIGATOR ON THE NEW STUDY. (Philadelphia, PA) – Like a key, SARS-CoV-2 – the virus that causes coronavirus disease 2019 (COVID-19) – attaches to specific molecules on the...
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Unlocking the mystery of tau for treatment of neurodegenerative diseases
by Nagoya University Under normal physiological conditions, FUS and SFPQ interact in the nucleus of nerve cells and regulate the alternative splicing of MAPT by excising exon 10. When this functional machinery is impaired, the splicing ratio of MAPT exon 10+/exon 10- is increased, which in turn results in an increased 4R-Tau/3R-Tau ratio. The findings...
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Investigational drug stops toxic proteins tied to neurodegenerative diseases
by Melissa Moody, Perelman School of Medicine at the University of Pennsylvania An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein’s buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at Penn...
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Are antivitamins the new antibiotics?
Research team from University of Göttingen develops drug approach against bacterial infections UNIVERSITY OF GÖTTINGEN FIRST AUTHOR DR. RABE VON PAPPENHEIM EXAMINES PROTEIN CRYSTALS OF A BACTERIAL ENZYME THAT WAS “POISONED ” WITH AN ANTIVITAMIN. view more CREDIT: LISA-MARIE FUNK Antibiotics are among the most important discoveries of modern medicine and have saved millions of...
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Cellulose wound dressing uses peptides to kill bacteria
By Ben Coxworth August 11, 2020 Staphylococci bacteria proved to be no match for the peptide-boosted cellulose fibers katerynakon/Depositphotos VIEW 1 IMAGES Although it’s vitally important to keep wounds free of harmful bacteria, antibacterial ointments have to be regularly reapplied, requiring bandages to be removed. A new wound dressing, however, is claimed to continuously kill...
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‘AeroNabs’ Promise Powerful, Inhalable Protection Against COVID-19
As the world awaits vaccines to bring the COVID-19 pandemic under control, UC San Francisco scientists have devised a novel approach to halting the spread of SARS-CoV-2, the virus that causes the disease. Led by UCSF graduate student Michael Schoof, a team of researchers engineered a completely synthetic, production-ready molecule that straitjackets the crucial SARS-CoV-2...
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Scientists identify new target for wide array of cancers
by Brian Wallheimer, Purdue University Many types of human cancers exhibit changes in kinase and phosphatase balances. Drugs that inhibit kinase activity have shown success in the clinic as cancer therapeutics, but the phosphatases still remain a largely underexploited target class due primarily to the lack of understanding of how they cause diseases. Purdue University’s...
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New light shed on cell migration
This news or article is intended for readers with certain scientific or professional knowledge in the field. Researchers at the IRCM, IRIC and University of Cambridge work together to reveal a mechanism involved in the formation of metastases. The 3D structure of the ELMO / DOCK2 complex, an important molecular machine that plays a crucial role in...
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Researchers uncover how cells interact with supporting proteins to heal wounds
When we get a wound on our skin, the cells in our bodies quickly mobilize to repair it. While it has been known how cells heal wounds and how scars form, a team led by researchers from Washington University in St. Louis has determined for the first time how the process begins, which may provide...